抄録
A number of studies have identified transforming growth factor-β (TGF-β) as a critical factor in renal diseases such as glomerulosclerosis and mesangioproliferative glomerulonephritis. TGF-β stimulates proliferation of mesangial cells, production of extracellular matrix components and induces epithelial-mesenchymal transformation in renal tissue, which plays a critical role in the pathogenesis of renal injury. Thus, TGF-β is a treatment target in renal diseases. However, progressive renal diseases cannot be cured with present medical technologies. We have developed ribozymes and a novel gene silencer pyrrole-imidazole polyamide targeted to TGF-β that effectively ameliorate renal injury in hypertensive rats.
| 本文言語 | 英語 |
|---|---|
| ページ（範囲） | 708-715 |
| ページ数 | 8 |
| ジャーナル | Journal of Nephrology |
| 巻 | 22 |
| 号 | 6 |
| 出版ステータス | 出版済み - 2009 |