Thromboembolisms in Advanced Pancreatic Cancer: A Retrospective Analysis of 475 Patients

Kazunaga Ishigaki, Yousuke Nakai, Hiroyuki Isayama, Kei Saito, Tsuyoshi Hamada, Naminatsu Takahara, Suguru Mizuno, Dai Mohri, Hirofumi Kogure, Saburo Matsubara, Natsuyo Yamamoto, Minoru Tada, Kazuhiko Koike

研究成果: ジャーナルへの寄稿記事査読

20 被引用数 (Scopus)

抄録

Objectives Pancreatic cancer is reported to be highly associated with thromboembolism (TE). The aim of this analysis is to clarify risk factors for TE and its clinical impact in Japanese patients with pancreatic cancer. Methods Data on consecutive pancreatic cancer patients receiving systemic chemotherapy between August 1999 and July 2015 were retrospectively studied. Both symptomatic and asymptomatic, arterial and venous TEs were included in the analysis. Risk factors for TE development were analyzed using a proportional hazards model with death without TE as a competing risk. The impact of TE on survival was also evaluated using a time-dependent covariate multiple Cox model. Results A total of 475 patients were included in the analysis, and 57 TEs (12%) were identified: 45 venous TEs and 12 arterial TEs. The median time to TE was 169 days and the median survival from TE was 65 days. Liver metastasis was the only significant risk factor for TE (subdistribution hazards ratio, 2.15; P = 0.01), and TE was significantly associated with poor prognosis (hazards ratio, 3.31; P < 0.01). Conclusions Thromboembolism was not uncommon in Japanese patients receiving chemotherapy for advanced pancreatic cancer and was associated with poor prognosis. Liver metastasis was the risk factor for TE.

本文言語英語
ページ(範囲)1069-1075
ページ数7
ジャーナルPancreas
46
8
DOI
出版ステータス出版済み - 1 9月 2017
外部発表はい

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