The involvement of src in airway inflammation induced by repeated exposure to lipopolysaccharide in mice

Yuki Nishimoto, Hironobu Yasuda, Keita Masuko, Yoshito Usui, Keitaro Ueda, Genki Kimura, Kazuhiro Ito, Yasuo Kizawa

研究成果: ジャーナルへの寄稿記事査読

3 被引用数 (Scopus)

抄録

Corticosteroid insensitive airway inflammation is one of major barrier to effective managements of chronic airway diseases, such as chronic obstructive pulmonary disease (COPD) and severe asthma. The role of nonreceptor tyrosine kinase Src is important in airway inflammation in mice models of atopic asthma and COPD. Thus, in this study, we determined the effects of Src inhibitor, dasatinib, on airway inflammation induced by repeated intranasal exposure to lipopolysaccharide (LPS). Male mice (A/J strain, 5 weeks old) were intranasally exposed to LPS twice daily for 3 d, and dasatinib was intranasally treated 2 h prior to each LPS exposure. A day after the last stimulation, lungs and bronchoalveolar lavage fluid (BALF) were collected. Dasatinib attenuated the accumulation of inflammatory cells in lungs, and the increase in the numbers of inflammatory cells and the accumulation of cytokines/chemokines in BALF in a dose dependent manner. Therefore, this study suggested that targeting the Src can provide a new therapeutic approach for corticosteroid insensitive pulmonary diseases.

本文言語英語
ページ(範囲)1211-1217
ページ数7
ジャーナルYakugaku Zasshi
139
9
DOI
出版ステータス出版済み - 2019

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