Roles of peptidyl prolyl isomerase Pin1 in viral propagation

Machi Kanna, Yusuke Nakatsu, Takeshi Yamamotoya, Jeffrey Encinas, Hisanaka Ito, Takayoshi Okabe, Tomoichiro Asano, Takemasa Sakaguchi

研究成果: ジャーナルへの寄稿総説査読

7 被引用数 (Scopus)

抄録

Peptidyl-prolyl isomerase (PPIase) is a unique enzyme that promotes cis-trans isomerization of a proline residue of a target protein. Peptidyl-prolyl cis-trans isomerase NIMA (never in mitosis A)-interacting 1 (Pin1) is a PPIase that binds to the pSer/pThr-Pro motif of target proteins and isomerizes their prolines. Pin1 has been reported to be involved in cancer development, obesity, aging, and Alzheimer’s disease and has been shown to promote the growth of several viruses including SARS-CoV-2. Pin1 enhances the efficiency of viral infection by promoting uncoating and integration of the human immunodeficiency virus. It has also been shown that Pin1 interacts with hepatitis B virus proteins and participates in viral replication. Furthermore, Pin1 promotes not only viral proliferation but also the progression of virus-induced tumorigenesis. In this review, we focus on the effects of Pin1 on the proliferation of various viruses and discuss the underlying molecular mechanisms.

本文言語英語
論文番号1005325
ジャーナルFrontiers in Cell and Developmental Biology
10
DOI
出版ステータス出版済み - 25 10月 2022
外部発表はい

フィンガープリント

「Roles of peptidyl prolyl isomerase Pin1 in viral propagation」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル