Relationship of systemic pentraxin-3 values with coronary plaque components on optical coherence tomography and post-percutaneous coronary intervention outcomes in patients with stable angina pectoris

Shigeki Kimura, Tomoyo Sugiyama, Keiichi Hishikari, Shun Nakagama, Shun Nakamura, Toru Misawa, Masafumi Mizusawa, Kazuto Hayasaka, Yosuke Yamakami, Yuichiro Sagawa, Keisuke Kojima, Hirofumi Ohtani, Hiroyuki Hikita, Atsushi Takahashi

研究成果: ジャーナルへの寄稿記事査読

11 被引用数 (Scopus)

抄録

Background and aims: Elevated pentraxin-3 (PTX3) values are associated with vulnerable plaque existence and poor outcomes in acute coronary syndrome patients. The clinical significance of PTX3 values in stable angina pectoris (SAP) patients is, however, undetermined. We investigated the relationship of systemic PTX3 values and coronary plaque components and post-percutaneous coronary intervention (PCI) outcomes in SAP patients. Methods: We included 93 consecutive de-novo lesions in 93 SAP patients with a normal pre-PCI high-sensitivity cardiac troponin-T (<0.014 ng/mL), undergoing pre- and post-PCI optical coherence tomography (OCT). Systemic PTX3 values were obtained immediately pre- and post-PCI, at 24-h and 9-month post-PCI. Results: Peak post-PCI PTX3 values correlated with thinnest fibrous cap thickness (r = −0.23, p = 0.03) and lipid length (r = 0.24, p = 0.03), and were higher in patients with lesions having OCT-derived thin-cap fibroatheroma (6.67 (3.19–7.33) vs. 3.13 (2.34–4.11) ng/mL, p = 0.04) and post-stenting irregular tissue protrusion (4.76 (3.31–6.80) vs. 2.98 (2.23–4.06) ng/mL, p = 0.003) than in those without. At 9-month follow-up, cardiac event-free survival was poorer in patients with a peak post-PCI PTX3 value ≥ 4.08 ng/mL (upper tertile) (log-rank test χ2 = 9.0; p = 0.003). Multivariate Cox regression analysis showed a peak post-PCI PTX3 value ≥ 4.08 ng/mL as an independent predictor of MACE (hazard ratio, 3.915; 95% CI, 1.129–13.583; p = 0.03). Conclusions: Peak post-PCI PTX3 values correlated with pre-PCI plaque characteristics and post-PCI outcomes, providing a good prognostic factor of outcomes in SAP patients undergoing elective PCI.

本文言語英語
ページ(範囲)127-135
ページ数9
ジャーナルAtherosclerosis
292
DOI
出版ステータス出版済み - 1月 2020
外部発表はい

フィンガープリント

「Relationship of systemic pentraxin-3 values with coronary plaque components on optical coherence tomography and post-percutaneous coronary intervention outcomes in patients with stable angina pectoris」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル