TY - JOUR
T1 - Relationship between symptom dimensions and brain morphology in obsessive-compulsive disorder
AU - Hirose, Motohisa
AU - Hirano, Yoshiyuki
AU - Nemoto, Kiyotaka
AU - Sutoh, Chihiro
AU - Asano, Kenichi
AU - Miyata, Haruko
AU - Matsumoto, Junko
AU - Nakazato, Michiko
AU - Matsumoto, Koji
AU - Masuda, Yoshitada
AU - Iyo, Masaomi
AU - Shimizu, Eiji
AU - Nakagawa, Akiko
N1 - Publisher Copyright:
© 2016, Springer Science+Business Media New York.
PY - 2017/10/1
Y1 - 2017/10/1
N2 - Obsessive-compulsive disorder (OCD) is known as a clinically heterogeneous disorder characterized by symptom dimensions. Although substantial numbers of neuroimaging studies have demonstrated the presence of brain abnormalities in OCD, their results are controversial. The clinical heterogeneity of OCD could be one of the reasons for this. It has been hypothesized that certain brain regions contributed to the respective obsessive-compulsive dimensions. In this study, we investigated the relationship between symptom dimensions of OCD and brain morphology using voxel-based morphometry to discover the specific regions showing alterations in the respective dimensions of obsessive-compulsive symptoms. The severities of symptom dimensions in thirty-three patients with OCD were assessed using Obsessive-Compulsive Inventory-Revised (OCI-R). Along with numerous MRI studies pointing out brain abnormalities in autistic spectrum disorder (ASD) patients, a previous study reported a positive correlation between ASD traits and regional gray matter volume in the left dorsolateral prefrontal cortex and amygdala in OCD patients. We investigated the correlation between gray and white matter volumes at the whole brain level and each symptom dimension score, treating all remaining dimension scores, age, gender, and ASD traits as confounding covariates. Our results revealed a significant negative correlation between washing symptom dimension score and gray matter volume in the right thalamus and a significant negative correlation between hoarding symptom dimension score and white matter volume in the left angular gyrus. Although our result was preliminary, our findings indicated that there were specific brain regions in gray and white matter that contributed to symptom dimensions in OCD patients.
AB - Obsessive-compulsive disorder (OCD) is known as a clinically heterogeneous disorder characterized by symptom dimensions. Although substantial numbers of neuroimaging studies have demonstrated the presence of brain abnormalities in OCD, their results are controversial. The clinical heterogeneity of OCD could be one of the reasons for this. It has been hypothesized that certain brain regions contributed to the respective obsessive-compulsive dimensions. In this study, we investigated the relationship between symptom dimensions of OCD and brain morphology using voxel-based morphometry to discover the specific regions showing alterations in the respective dimensions of obsessive-compulsive symptoms. The severities of symptom dimensions in thirty-three patients with OCD were assessed using Obsessive-Compulsive Inventory-Revised (OCI-R). Along with numerous MRI studies pointing out brain abnormalities in autistic spectrum disorder (ASD) patients, a previous study reported a positive correlation between ASD traits and regional gray matter volume in the left dorsolateral prefrontal cortex and amygdala in OCD patients. We investigated the correlation between gray and white matter volumes at the whole brain level and each symptom dimension score, treating all remaining dimension scores, age, gender, and ASD traits as confounding covariates. Our results revealed a significant negative correlation between washing symptom dimension score and gray matter volume in the right thalamus and a significant negative correlation between hoarding symptom dimension score and white matter volume in the left angular gyrus. Although our result was preliminary, our findings indicated that there were specific brain regions in gray and white matter that contributed to symptom dimensions in OCD patients.
KW - Hoarding symptom
KW - Obsessive-compulsive disorder
KW - Obsessive-compulsive inventory-revised
KW - Thalamus
KW - Voxel-based morphometry
KW - Washing symptom
UR - http://www.scopus.com/inward/record.url?scp=85042398692&partnerID=8YFLogxK
U2 - 10.1007/s11682-016-9611-9
DO - 10.1007/s11682-016-9611-9
M3 - Article
C2 - 27730476
AN - SCOPUS:85042398692
SN - 1931-7557
VL - 11
SP - 1326
EP - 1333
JO - Brain Imaging and Behavior
JF - Brain Imaging and Behavior
IS - 5
ER -