TY - JOUR
T1 - Profiling of Radicular Cyst and Odontogenic Keratocyst Cytokine Production Suggests Common Growth Mechanisms
AU - Hayashi, Makoto
AU - Ohshima, Takafumi
AU - Ohshima, Mitsuhiro
AU - Yamaguchi, Yoko
AU - Miyata, Hirofumi
AU - Takeichi, Osamu
AU - Ogiso, Bunnai
AU - Ito, Koichi
AU - Östman, Arne
AU - Otsuka, Kichibee
PY - 2008/1
Y1 - 2008/1
N2 - The aim of this study was to compare the cytokine expression profiles of cyst fluids (CFs) and tissue culture supernatants (SUPs) from 7 radicular cysts (RCs) and 7 odontogenic keratocysts (OKCs) by using Human Cytokine Antibody Array to identify the specific cytokines involved in formation and expansion of RCs and OKCs, respectively. There were significant differences in relative expression levels of IL-1β, MCP1, MIP1β, FGF-9, GDNF, HGF, IGFBP-3, Ang, IP-10, MIF, OPG, and TGF-β2 between RC-CF and OKC-CF (P < .05). On the other hand, the cytokine expression patterns of RC-SUP (HGF, IL-8, NAP-2, IL-6, TIMP-1 and 2, GRO, IP-10, and Ang) were similar to those of OKC-SUP. Only the relative expression level of GRO differed between RC-SUP and OKC-SUP (P < .05). The similarities of cytokine production by tissue cultures derived from RC and OKC indicate that the expansion mechanisms of RC and OKC might involve similar biologic mechanisms other than infection.
AB - The aim of this study was to compare the cytokine expression profiles of cyst fluids (CFs) and tissue culture supernatants (SUPs) from 7 radicular cysts (RCs) and 7 odontogenic keratocysts (OKCs) by using Human Cytokine Antibody Array to identify the specific cytokines involved in formation and expansion of RCs and OKCs, respectively. There were significant differences in relative expression levels of IL-1β, MCP1, MIP1β, FGF-9, GDNF, HGF, IGFBP-3, Ang, IP-10, MIF, OPG, and TGF-β2 between RC-CF and OKC-CF (P < .05). On the other hand, the cytokine expression patterns of RC-SUP (HGF, IL-8, NAP-2, IL-6, TIMP-1 and 2, GRO, IP-10, and Ang) were similar to those of OKC-SUP. Only the relative expression level of GRO differed between RC-SUP and OKC-SUP (P < .05). The similarities of cytokine production by tissue cultures derived from RC and OKC indicate that the expansion mechanisms of RC and OKC might involve similar biologic mechanisms other than infection.
KW - Cytokine profile
KW - odontogenic keratocyst
KW - radicular cyst
UR - http://www.scopus.com/inward/record.url?scp=37249051003&partnerID=8YFLogxK
U2 - 10.1016/j.joen.2007.08.020
DO - 10.1016/j.joen.2007.08.020
M3 - Article
C2 - 18155485
AN - SCOPUS:37249051003
SN - 0099-2399
VL - 34
SP - 14
EP - 21
JO - Journal of Endodontics
JF - Journal of Endodontics
IS - 1
ER -