Parameters Influencing Brain Oxygen Measurement by Regional Oxygen Saturation in Postcardiac Arrest Patients with Targeted Temperature Management

In several studies, regional cerebral oxygen saturation (rSO₂) has been measured in patients with postcardiac arrest syndrome (PCAS) to analyze the brain's metabolic status. However, the significance of rSO₂ in PCAS patients remains unclear. In the present study, we investigated the relationship between rSO₂ and physiological parameters. Comatose survivors of out-of-hospital PCAS with targeted temperature management (TTM) at 34°C for 24 hours were included. All patients were monitored for their rSO₂ and additional parameters (arterial oxygen saturation [SaO₂], hemoglobin [Hb], mean arterial pressure [MAP], arterial carbon dioxide pressure [PaCO₂], and body temperature]) measured at the start of monitoring and 24 and 48 hours after return of spontaneous circulation (ROSC). Patients were divided into favorable and unfavorable groups, and the correlation between rSO₂ and these physiological parameters was evaluated by multiple regression analysis. Forty-nine patients were included in the study, with 15 in the favorable group and 34 in the unfavorable group. There was no significant difference in the rSO₂ value between the two groups at any time point. The multiple regression analysis of the favorable group revealed a moderate correlation between rSO₂ and SaO₂, Hb, and PaCO₂ only at 24 hours (coefficients: 0.482, 0.422, and 0.531, respectively), whereas that of the unfavorable group revealed moderate correlations between rSO₂ and Hb values at all time points, PaCO₂ at 24 hours and MAP at 24 and 48 hours. rSO₂ was moderately correlated to MAP in unfavorable patients. To optimize brain oxygen metabolic balance for PCAS patients with TTM measuring rSO₂, we suggest total evaluation of each parameters of SaO₂, Hb, MAP, and PaCO₂.