Occurrence of hepatitis in an elderly woman during the treatment of pembrolizumab for right advanced renal pelvis, ureteral cancer, and bladder cancer

Shinya Asatani; Tatsuo Kanda; Masayuki Honda; Tomotaka Ishii; Yoichiro Yamana; Tomohiro Kaneko; Taku Mizutani; Hiroshi Takahashi; Mariko Kumagawa; Reina Sasaki; Ryota Masuzaki; Shini Kanezawa; Naoki Matsumoto; Kazushige Nirei; Hiroaki Yamagami; Mitsuhiko Moriyama

doi:10.1002/jgh3.12554

Occurrence of hepatitis in an elderly woman during the treatment of pembrolizumab for right advanced renal pelvis, ureteral cancer, and bladder cancer

Shinya Asatani, Tatsuo Kanda, Masayuki Honda, Tomotaka Ishii, Yoichiro Yamana, Tomohiro Kaneko, Taku Mizutani, Hiroshi Takahashi, Mariko Kumagawa, Reina Sasaki, Ryota Masuzaki, Shini Kanezawa, Naoki Matsumoto, Kazushige Nirei, Hiroaki Yamagami, Mitsuhiko Moriyama

医学部

Nihon University

研究成果: ジャーナルへの寄稿 › 記事 › 査読

抄録

Recently, the use of immune checkpoint inhibitors (ICIs) with or without chemotherapeutic agents has been increasing in the treatment for advanced cancer. Here, we report the occurrence of liver failure after the use of pembrolizumab in an 82-year-old woman with metastatic liver disease derived from right advanced renal pelvis, ureteral cancer, and bladder cancer. She was successfully treated with 0.6 mg/kg daily prednisolone. In patients treated with ICIs, ICI-induced hepatitis is occasionally observed. Even if patients are older, it appears important to diagnose and treat ICI-induced hepatitis earlier by multidisciplinary therapies including steroid treatment. This is a first report of pembrolizumab-induced liver failure in elder patient with age over 80 years. Even if patients are older, it appears important to diagnose and treat ICI-induced hepatitis earlier by multidisciplinary therapies including steroid treatment.

本文言語	英語
ページ（範囲）	722-724
ページ数	3
ジャーナル	JGH Open
巻	5
号	6
DOI	https://doi.org/10.1002/jgh3.12554
出版ステータス	出版済み - 6月 2021

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

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10.1002/jgh3.12554

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引用スタイル

Asatani, S., Kanda, T., Honda, M., Ishii, T., Yamana, Y., Kaneko, T., Mizutani, T., Takahashi, H., Kumagawa, M., Sasaki, R., Masuzaki, R., Kanezawa, S., Matsumoto, N., Nirei, K., Yamagami, H., & Moriyama, M. (2021). Occurrence of hepatitis in an elderly woman during the treatment of pembrolizumab for right advanced renal pelvis, ureteral cancer, and bladder cancer. JGH Open, 5(6), 722-724. https://doi.org/10.1002/jgh3.12554

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title = "Occurrence of hepatitis in an elderly woman during the treatment of pembrolizumab for right advanced renal pelvis, ureteral cancer, and bladder cancer",

abstract = "Recently, the use of immune checkpoint inhibitors (ICIs) with or without chemotherapeutic agents has been increasing in the treatment for advanced cancer. Here, we report the occurrence of liver failure after the use of pembrolizumab in an 82-year-old woman with metastatic liver disease derived from right advanced renal pelvis, ureteral cancer, and bladder cancer. She was successfully treated with 0.6 mg/kg daily prednisolone. In patients treated with ICIs, ICI-induced hepatitis is occasionally observed. Even if patients are older, it appears important to diagnose and treat ICI-induced hepatitis earlier by multidisciplinary therapies including steroid treatment. This is a first report of pembrolizumab-induced liver failure in elder patient with age over 80 years. Even if patients are older, it appears important to diagnose and treat ICI-induced hepatitis earlier by multidisciplinary therapies including steroid treatment.",

keywords = "hepatitis, immune-related adverse event, pembrolizumab, renal pelvis and ureteral cancer, steroid",

author = "Shinya Asatani and Tatsuo Kanda and Masayuki Honda and Tomotaka Ishii and Yoichiro Yamana and Tomohiro Kaneko and Taku Mizutani and Hiroshi Takahashi and Mariko Kumagawa and Reina Sasaki and Ryota Masuzaki and Shini Kanezawa and Naoki Matsumoto and Kazushige Nirei and Hiroaki Yamagami and Mitsuhiko Moriyama",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors. JGH Open published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.",

year = "2021",

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doi = "10.1002/jgh3.12554",

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Asatani, S, Kanda, T, Honda, M, Ishii, T, Yamana, Y, Kaneko, T, Mizutani, T, Takahashi, H, Kumagawa, M, Sasaki, R, Masuzaki, R, Kanezawa, S, Matsumoto, N, Nirei, K, Yamagami, H & Moriyama, M 2021, 'Occurrence of hepatitis in an elderly woman during the treatment of pembrolizumab for right advanced renal pelvis, ureteral cancer, and bladder cancer', JGH Open, vol. 5, no. 6, pp. 722-724. https://doi.org/10.1002/jgh3.12554

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AU - Asatani, Shinya

AU - Kanda, Tatsuo

AU - Honda, Masayuki

AU - Ishii, Tomotaka

AU - Yamana, Yoichiro

AU - Kaneko, Tomohiro

AU - Mizutani, Taku

AU - Takahashi, Hiroshi

AU - Kumagawa, Mariko

AU - Sasaki, Reina

AU - Masuzaki, Ryota

AU - Kanezawa, Shini

AU - Matsumoto, Naoki

AU - Nirei, Kazushige

AU - Yamagami, Hiroaki

AU - Moriyama, Mitsuhiko

PY - 2021/6

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N2 - Recently, the use of immune checkpoint inhibitors (ICIs) with or without chemotherapeutic agents has been increasing in the treatment for advanced cancer. Here, we report the occurrence of liver failure after the use of pembrolizumab in an 82-year-old woman with metastatic liver disease derived from right advanced renal pelvis, ureteral cancer, and bladder cancer. She was successfully treated with 0.6 mg/kg daily prednisolone. In patients treated with ICIs, ICI-induced hepatitis is occasionally observed. Even if patients are older, it appears important to diagnose and treat ICI-induced hepatitis earlier by multidisciplinary therapies including steroid treatment. This is a first report of pembrolizumab-induced liver failure in elder patient with age over 80 years. Even if patients are older, it appears important to diagnose and treat ICI-induced hepatitis earlier by multidisciplinary therapies including steroid treatment.

AB - Recently, the use of immune checkpoint inhibitors (ICIs) with or without chemotherapeutic agents has been increasing in the treatment for advanced cancer. Here, we report the occurrence of liver failure after the use of pembrolizumab in an 82-year-old woman with metastatic liver disease derived from right advanced renal pelvis, ureteral cancer, and bladder cancer. She was successfully treated with 0.6 mg/kg daily prednisolone. In patients treated with ICIs, ICI-induced hepatitis is occasionally observed. Even if patients are older, it appears important to diagnose and treat ICI-induced hepatitis earlier by multidisciplinary therapies including steroid treatment. This is a first report of pembrolizumab-induced liver failure in elder patient with age over 80 years. Even if patients are older, it appears important to diagnose and treat ICI-induced hepatitis earlier by multidisciplinary therapies including steroid treatment.

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