Micro-CT observation of in vivo temporal change in mandibular condyle morphology in BMAL1 knockout mice

Shigenori Hirai, Yusuke Hayashi, Motohiro Ito, Toshihiko Amemiya, Ko Dezawa, Yoshinori Arai, Ken Ichiro Ejima, Shigeki Shimba, Kazuya Honda

研究成果: ジャーナルへの寄稿記事査読

5 被引用数 (Scopus)

抄録

Brain and muscle Arnt-like protein-1 (BMAL1) knockout mice exhibit accelerated aging, abnormal glucose metabolism, and impaired adipo-cyte differentiation, among other phenotypes, which are effects associated with the BMAL1 gene. No study has investigated temporal changes in the deformation of the mandibular condyle and the presence of calcification in areas surrounding the mandibular condyle. In a study of 12 C57/BL strain mice under inhalation anesthesia, we collected images of the mandibular condyle at 6 weeks after birth and then every 5 weeks from 10 to 25 weeks after birth. At 25 weeks, deformation of the mandibular condyle was seen in 8 of 12 joints in BMAL1 knockout mice and in 2 of 12 joints in wild-type mice. At 20 and 25 weeks, deformation in areas surrounding the mandibular condyle, which are known to undergo calcification, was seen in 2 of 12 joints in BMAL1 knockout mice and in 0 of 12 joints in wild-type mice. BMAL1 knockout mice exhibited premature aging of the mandibular condyle, which suggests that circadian rhythms affect mandibular condyle morphology.

本文言語英語
ページ(範囲)473-478
ページ数6
ジャーナルJournal of Oral Science
60
4
DOI
出版ステータス出版済み - 12月 2018

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