Mariannamides A and B, new cyclic octapeptides isolated from Mariannaea elegans NBRC102301

Kan'ichiro Ishiuchi; Dai Hirose; Taishi Kondo; Kohei Watanabe; Kazuyoshi Terasaka; Toshiaki Makino

doi:10.1016/j.bmcl.2019.126946

Mariannamides A and B, new cyclic octapeptides isolated from Mariannaea elegans NBRC102301

Kan'ichiro Ishiuchi, Dai Hirose, Taishi Kondo, Kohei Watanabe, Kazuyoshi Terasaka, Toshiaki Makino

薬学部

研究成果: ジャーナルへの寄稿 › 記事 › 査読

6 被引用数 (Scopus)

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Two new cyclic octapeptides, mariannamides A (1) and B (2), have been isolated from Mariannaea elegans NBRC102301, a Pinus densiflora-derived filamentous fungus. Their structures were elucidated to be cyclo-(L-Leu¹-L-Pro¹-L-Pro²-L-Leu²-L-Ile¹-L-Pro³-L-Val¹-L-Ile²) and cyclo-(L-Leu¹-L-Pro¹-L-Pro²-L-Leu²-L-Ile¹-L-Pro³-L-Val¹-L-Val²) based on spectroscopic data and Marfey's method. Mariannamide A (1) promoted mRNA expression of sirtuin 1 (SIRT1) in C2C12 cells, a mouse skeletal muscle myoblast cell line, and showed the antimicrobial activity against Escherichia coli and Cryptococcus neoformans.

本文言語	英語
論文番号	126946
ジャーナル	Bioorganic and Medicinal Chemistry Letters
巻	30
号	4
DOI	https://doi.org/10.1016/j.bmcl.2019.126946
出版ステータス	出版済み - 15 2月 2020

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title = "Mariannamides A and B, new cyclic octapeptides isolated from Mariannaea elegans NBRC102301",

abstract = "Two new cyclic octapeptides, mariannamides A (1) and B (2), have been isolated from Mariannaea elegans NBRC102301, a Pinus densiflora-derived filamentous fungus. Their structures were elucidated to be cyclo-(L-Leu1-L-Pro1-L-Pro2-L-Leu2-L-Ile1-L-Pro3-L-Val1-L-Ile2) and cyclo-(L-Leu1-L-Pro1-L-Pro2-L-Leu2-L-Ile1-L-Pro3-L-Val1-L-Val2) based on spectroscopic data and Marfey's method. Mariannamide A (1) promoted mRNA expression of sirtuin 1 (SIRT1) in C2C12 cells, a mouse skeletal muscle myoblast cell line, and showed the antimicrobial activity against Escherichia coli and Cryptococcus neoformans.",

keywords = "Cyclic peptides, Mariannaea elegans NBRC102301, Mariannamides A-B, Sirtuin 1",

author = "Kan'ichiro Ishiuchi and Dai Hirose and Taishi Kondo and Kohei Watanabe and Kazuyoshi Terasaka and Toshiaki Makino",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",

year = "2020",

month = feb,

day = "15",

doi = "10.1016/j.bmcl.2019.126946",

language = "English",

volume = "30",

journal = "Bioorganic and Medicinal Chemistry Letters",

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T1 - Mariannamides A and B, new cyclic octapeptides isolated from Mariannaea elegans NBRC102301

AU - Ishiuchi, Kan'ichiro

AU - Hirose, Dai

AU - Kondo, Taishi

AU - Watanabe, Kohei

AU - Terasaka, Kazuyoshi

AU - Makino, Toshiaki

PY - 2020/2/15

Y1 - 2020/2/15

N2 - Two new cyclic octapeptides, mariannamides A (1) and B (2), have been isolated from Mariannaea elegans NBRC102301, a Pinus densiflora-derived filamentous fungus. Their structures were elucidated to be cyclo-(L-Leu1-L-Pro1-L-Pro2-L-Leu2-L-Ile1-L-Pro3-L-Val1-L-Ile2) and cyclo-(L-Leu1-L-Pro1-L-Pro2-L-Leu2-L-Ile1-L-Pro3-L-Val1-L-Val2) based on spectroscopic data and Marfey's method. Mariannamide A (1) promoted mRNA expression of sirtuin 1 (SIRT1) in C2C12 cells, a mouse skeletal muscle myoblast cell line, and showed the antimicrobial activity against Escherichia coli and Cryptococcus neoformans.

AB - Two new cyclic octapeptides, mariannamides A (1) and B (2), have been isolated from Mariannaea elegans NBRC102301, a Pinus densiflora-derived filamentous fungus. Their structures were elucidated to be cyclo-(L-Leu1-L-Pro1-L-Pro2-L-Leu2-L-Ile1-L-Pro3-L-Val1-L-Ile2) and cyclo-(L-Leu1-L-Pro1-L-Pro2-L-Leu2-L-Ile1-L-Pro3-L-Val1-L-Val2) based on spectroscopic data and Marfey's method. Mariannamide A (1) promoted mRNA expression of sirtuin 1 (SIRT1) in C2C12 cells, a mouse skeletal muscle myoblast cell line, and showed the antimicrobial activity against Escherichia coli and Cryptococcus neoformans.

KW - Cyclic peptides

KW - Mariannaea elegans NBRC102301

KW - Mariannamides A-B

KW - Sirtuin 1

UR - https://www.scopus.com/pages/publications/85077673800

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DO - 10.1016/j.bmcl.2019.126946

M3 - Article

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AN - SCOPUS:85077673800

SN - 0960-894X

VL - 30

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 4

M1 - 126946

ER -

Mariannamides A and B, new cyclic octapeptides isolated from Mariannaea elegans NBRC102301

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