Mariannamides A and B, new cyclic octapeptides isolated from Mariannaea elegans NBRC102301

Kan'ichiro Ishiuchi, Dai Hirose, Taishi Kondo, Kohei Watanabe, Kazuyoshi Terasaka, Toshiaki Makino

研究成果: ジャーナルへの寄稿記事査読

6 被引用数 (Scopus)

抄録

Two new cyclic octapeptides, mariannamides A (1) and B (2), have been isolated from Mariannaea elegans NBRC102301, a Pinus densiflora-derived filamentous fungus. Their structures were elucidated to be cyclo-(L-Leu1-L-Pro1-L-Pro2-L-Leu2-L-Ile1-L-Pro3-L-Val1-L-Ile2) and cyclo-(L-Leu1-L-Pro1-L-Pro2-L-Leu2-L-Ile1-L-Pro3-L-Val1-L-Val2) based on spectroscopic data and Marfey's method. Mariannamide A (1) promoted mRNA expression of sirtuin 1 (SIRT1) in C2C12 cells, a mouse skeletal muscle myoblast cell line, and showed the antimicrobial activity against Escherichia coli and Cryptococcus neoformans.

本文言語英語
論文番号126946
ジャーナルBioorganic and Medicinal Chemistry Letters
30
4
DOI
出版ステータス出版済み - 15 2月 2020

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