抄録
We evaluated the significance of indoleamine 2,3-dioxygenase (IDO) activity in breast cancer patients with local recurrence or distant metastases. IDO activity can be determined using the tryptophan/kynurenine (Trp/Kyn) ratio. Trp and Kyn were measured by high-performance liquid chromatography (HPLC). The survival rate after recurrence was higher in the local recurrence group (n = 1l) than in the distant metastases group (n=26). The mean Trp/Kyn ratio was lower in the distant metastases group than in the local recurrence group. The mean Trp/Kyn ratio was also lower in patients who had multiple metastases than in patients who had a single metastatic lesion. The Trp/Kyn ratio decreased during chemotherapy in all patients who received chemotherapy.
本文言語 | 英語 |
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ページ(範囲) | 1304-1306 |
ページ数 | 3 |
ジャーナル | Japanese Journal of Cancer and Chemotherapy |
巻 | 41 |
号 | 10 |
出版ステータス | 出版済み - 1 10月 2014 |