Indoleamine 2,3-dioxygenase activity during long-term letrozole therapy for hormone receptor-positive breast cancer

Yuna Suzuki, Kenichi Sakurai, Keita Adachi, Hitomi Kubota, Shuhei Suzuki, Satsuki Takei, Yukiko Hara, Katsuhisa Enomoto, Tomohiro Hirano, Makoto Makishima

研究成果: ジャーナルへの寄稿記事査読

1 被引用数 (Scopus)

抄録

Endocrine therapy is effective for elderly patients who are diagnosed with estrogen receptor-positive breast cancer and cannot receive surgical treatment or chemotherapy because of advanced age. The duration of response in patients receiving letrozole is approximately 10.3 months. There are few cases with more than 3 years of response. We evaluated the significance of indoleamine 2, 3-dioxygenase (IDO) during letrozole therapy in long-term response. We measured IDO activity based on the tryptophan (TrpVkynurenine (Kyn) ratio. Trp and Kyn levels were measured using high-performance liquid chromatography (HPLC). The Trp/Kyn ratio decreased along with tumor reduction after letrozole therapy. These results suggest that measuring the Trp/Kyn ratio may be useful for evaluating immunological status during endocrine therapy in elderly patients with locally advanced breast cancer.

本文言語英語
ページ(範囲)1495-1497
ページ数3
ジャーナルJapanese Journal of Cancer and Chemotherapy
45
10
出版ステータス出版済み - 10月 2018
外部発表はい

フィンガープリント

「Indoleamine 2,3-dioxygenase activity during long-term letrozole therapy for hormone receptor-positive breast cancer」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル