External Validation of the HELT-E2S2 Score in Japanese Patients With Nonvalvular Atrial Fibrillation ― A Pooled Analysis of the RAFFINE and SAKURA Registries ―

Takahiro Yamauchi, Yasuo Okumura, Koichi Nagashima, Ryuta Watanabe, Yuki Saito, Katsuaki Yokoyama, Naoya Matsumoto, Katsumi Miyauchi, Sakiko Miyazaki, Hidemori Hayashi, Yuya Matsue, Yuji Nishizaki, Shuko Nojiri, Tohru Minamino, Hiroyuki Daida

研究成果: ジャーナルへの寄稿記事査読

1 被引用数 (Scopus)

抄録

Background: The HELT-E2S2 score, which assigns 1 point to Hypertension, Elderly aged 75–84 years, Low body mass index <18.5kg/m2, and Type of atrial fibrillation (AF: persistent/permanent), and 2 points to Extreme Elderly aged ≥85 years and previous Stroke, has been proposed as a new risk stratification for strokes in Japanese AF patients, but has not yet undergone external validation. Methods and Results: We evaluated the prognostic performance of the HELT-E2S2 score for stroke risk stratification using 2 large-scale registries in Japanese AF patients (n=7,020). During 23,241 person-years of follow-up (mean follow-up 1,208±450 days), 287 ischemic stroke events occurred. The C-statistic using the HELT-E2S2 score was 0.661 (95% confidence interval [CI], 0.629–0.692), which was numerically higher than with the CHADS2 score (0.644, 95% CI 0.613–0.675; P=0.15 vs. HELT-E2S2) or CHA2DS2-VASc score (0.650, 95% CI, 0.619–0.680; P=0.37 vs. HELT-E2S2). In the SAKURA AF Registry, the C-statistic of the HELT-E2S2 score was consistently higher than the CHADS2 and CHA2DS2-VASc scores across all 3 types of facilities comprising university hospitals, general hospitals, and clinics. However, in the RAFFINE Study, its superiority was only observed in general hospitals. Conclusions: The HELT-E2S2 score demonstrated potential value for risk stratification, particularly in a super-aged society such as Japan. However, its superiority over the CHADS2 or CHA2DS2-VASc scores may vary across different hospital settings.

本文言語英語
ページ(範囲)1777-1787
ページ数11
ジャーナルCirculation Journal
87
12
DOI
出版ステータス出版済み - 2023

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「External Validation of the HELT-E2S2 Score in Japanese Patients With Nonvalvular Atrial Fibrillation ― A Pooled Analysis of the RAFFINE and SAKURA Registries ―」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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