TY - JOUR
T1 - Effective new membrane for preventing postthoracotomy pleural adhesion by surface water induction technology
AU - Uemura, Akiko
AU - Nakata, Mary
AU - Goya, Seijirow
AU - Fukayama, Toshiharu
AU - Tanaka, Ryou
N1 - Publisher Copyright:
© 2017 Uemura et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2017/6
Y1 - 2017/6
N2 - Background: After thoracic surgery, adhesions between the pleura can cause substantial complications. This study investigated the effectiveness of a novel membrane utilizing surface water induction technology to prevent adhesions. Methods: Eight beagles were divided into an experimental group (five males) and a control group (three females). The experimental group underwent thoracotomy on both the left and right sides of the chest. Both sides received the membrane, and the membrane on one side was glued to the pleura using tissue adhesive. The control group underwent thoracotomy only on the left side. Two weeks postoperatively, all dogs were sacrificed and adhesions were evaluated macroscopically and microscopically. Results: Severe adhesion was seen between the parietal and visceral pleura in all control dogs, whereas the experimental group showed minor adhesion in only one dog on one side. Conclusions: Our novel anti-adhesive membrane appeared highly effective in preventing postthoracotomy pleural adhesions.
AB - Background: After thoracic surgery, adhesions between the pleura can cause substantial complications. This study investigated the effectiveness of a novel membrane utilizing surface water induction technology to prevent adhesions. Methods: Eight beagles were divided into an experimental group (five males) and a control group (three females). The experimental group underwent thoracotomy on both the left and right sides of the chest. Both sides received the membrane, and the membrane on one side was glued to the pleura using tissue adhesive. The control group underwent thoracotomy only on the left side. Two weeks postoperatively, all dogs were sacrificed and adhesions were evaluated macroscopically and microscopically. Results: Severe adhesion was seen between the parietal and visceral pleura in all control dogs, whereas the experimental group showed minor adhesion in only one dog on one side. Conclusions: Our novel anti-adhesive membrane appeared highly effective in preventing postthoracotomy pleural adhesions.
UR - http://www.scopus.com/inward/record.url?scp=85021352745&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0179815
DO - 10.1371/journal.pone.0179815
M3 - Article
C2 - 28654705
AN - SCOPUS:85021352745
SN - 1932-6203
VL - 12
JO - PLoS ONE
JF - PLoS ONE
IS - 6
M1 - e0179815
ER -