Effect of drug-coated balloon angioplasty on in-stent restenotic coronary lesions analyzed with optical coherence tomography and serial coronary artery angioscopy

Naotaka Akutsu, Akihito Ogaku, Yutaka Koyama, Hidesato Fujito, Yasunari Ebuchi, Suguru Migita, Tomoyuki Morikawa, Takehiro Tamaki, Takashi Mineki, Takaaki Kougo, Keisuke Kojima, Korehito Iida, Nobuhiro Murata, Toshihiko Nishida, Toru Oshima, Mitsumasa Sudo, Daisuke Kitano, Hironori Haruta, Daisuke Fukamachi, Tadateru TakayamaTakafumi Hiro, Atsushi Hirayama, Yasuo Okumura

研究成果: ジャーナルへの寄稿記事査読

3 被引用数 (Scopus)

抄録

Drug-coated balloon angioplasty (DCBA) has been recognized for its utility in preventing in-stent re-restenosis (ISR); however, imaging of the neointima immediately after treatment and during follow-up has only been described in a few case reports. This study aimed to determine the efficacy and mechanism of the DCBA using imaging studies both immediately after the DCBA and during the follow-up period. We enrolled 15 consecutive patients who underwent DCBA for in-stent restenosis (ISR). The in-stent neointimal volume was evaluated using optical coherence tomography (OCT), and the in-stent yellow grade was assessed using coronary angioscopy (CAS) immediately after DCBA and during the median follow-up period of 9 (8–15) months. The neointimal volume was significantly reduced from 77.1 ± 36.2 mm3 at baseline to 60.2 ± 23.9 mm3 immediately after DCBA (p = 0.0012 vs. baseline) and to 46.7 ± 21.9 mm3 during the follow-up (p = 0.0002 vs. post DCBA). The yellow grade of the residual plaques at the ISR lesion, which indicated plaque vulnerability, was significantly decreased in the follow-up CAG (from baseline: 1.79 ± 1.03, during the follow-up: 0.76 ± 0.82; p < 0.0001). These data suggest that DCBA may inhibit neointimal formation and provide angioscopic intimal stabilization for ISR lesions.

本文言語英語
ページ(範囲)1925-1935
ページ数11
ジャーナルHeart and Vessels
34
12
DOI
出版ステータス出版済み - 1 12月 2019

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