Concentrations of very long-chain fatty acid in whole blood are associated with cardiovascular risk factors in children

Aya Okahashi; Tomoo Okada; Emiko Saito; Michio Miyashita; Yuki Kuromori; Fujihiko Iwata; Mitsuhiko Hara; Hideo Mugishima; Yohei Kitamura; Takashi Shimizu

doi:10.1016/j.cca.2008.12.013

Concentrations of very long-chain fatty acid in whole blood are associated with cardiovascular risk factors in children

Aya Okahashi, Tomoo Okada, Emiko Saito, Michio Miyashita, Yuki Kuromori, Fujihiko Iwata, Mitsuhiko Hara, Hideo Mugishima, Yohei Kitamura, Takashi Shimizu

医学部

研究成果: ジャーナルへの寄稿 › 記事 › 査読

4 被引用数 (Scopus)

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Background: Fatty acid metabolism has a close relationship with metabolic syndrome. Saturated very long-chain fatty acid (hexacosanoic acid; C26:0) was recently reported to be associated with cardiovascular risk factors in adults. Methods: Eighty-eight children (47 male, 41 female; average age, 10.9 y) participated in this study. Concentrations of C26:0 in whole blood were measured. Results: Compared with reported concentrations in the whole blood of adults, children had lower C26:0 concentrations, which had a close relationship with abdominal obesity, increased concentrations of low-density lipoprotein cholesterol and high blood pressure. C26:0 concentrations increased with increasing number of risk factors. Conclusions: Elevation of C26:0 concentrations may be one of the metabolic features of children with cardiovascular risk factors.

本文言語	英語
ページ（範囲）	141-143
ページ数	3
ジャーナル	Clinica Chimica Acta
巻	401
号	1-2
DOI	https://doi.org/10.1016/j.cca.2008.12.013
出版ステータス	出版済み - 3月 2009

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10.1016/j.cca.2008.12.013

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@article{a498a51464ea44fe919152544d59f157,

title = "Concentrations of very long-chain fatty acid in whole blood are associated with cardiovascular risk factors in children",

abstract = "Background: Fatty acid metabolism has a close relationship with metabolic syndrome. Saturated very long-chain fatty acid (hexacosanoic acid; C26:0) was recently reported to be associated with cardiovascular risk factors in adults. Methods: Eighty-eight children (47 male, 41 female; average age, 10.9 y) participated in this study. Concentrations of C26:0 in whole blood were measured. Results: Compared with reported concentrations in the whole blood of adults, children had lower C26:0 concentrations, which had a close relationship with abdominal obesity, increased concentrations of low-density lipoprotein cholesterol and high blood pressure. C26:0 concentrations increased with increasing number of risk factors. Conclusions: Elevation of C26:0 concentrations may be one of the metabolic features of children with cardiovascular risk factors.",

keywords = "Abdominal obesity, Childhood obesity, Hexacosanoic acid(C26:0), Very long-chain fatty acid",

author = "Aya Okahashi and Tomoo Okada and Emiko Saito and Michio Miyashita and Yuki Kuromori and Fujihiko Iwata and Mitsuhiko Hara and Hideo Mugishima and Yohei Kitamura and Takashi Shimizu",

year = "2009",

month = mar,

doi = "10.1016/j.cca.2008.12.013",

language = "English",

volume = "401",

pages = "141--143",

journal = "Clinica Chimica Acta",

issn = "0009-8981",

publisher = "Elsevier B.V.",

number = "1-2",

}

TY - JOUR

T1 - Concentrations of very long-chain fatty acid in whole blood are associated with cardiovascular risk factors in children

AU - Okahashi, Aya

AU - Okada, Tomoo

AU - Saito, Emiko

AU - Miyashita, Michio

AU - Kuromori, Yuki

AU - Iwata, Fujihiko

AU - Hara, Mitsuhiko

AU - Mugishima, Hideo

AU - Kitamura, Yohei

AU - Shimizu, Takashi

PY - 2009/3

Y1 - 2009/3

N2 - Background: Fatty acid metabolism has a close relationship with metabolic syndrome. Saturated very long-chain fatty acid (hexacosanoic acid; C26:0) was recently reported to be associated with cardiovascular risk factors in adults. Methods: Eighty-eight children (47 male, 41 female; average age, 10.9 y) participated in this study. Concentrations of C26:0 in whole blood were measured. Results: Compared with reported concentrations in the whole blood of adults, children had lower C26:0 concentrations, which had a close relationship with abdominal obesity, increased concentrations of low-density lipoprotein cholesterol and high blood pressure. C26:0 concentrations increased with increasing number of risk factors. Conclusions: Elevation of C26:0 concentrations may be one of the metabolic features of children with cardiovascular risk factors.

AB - Background: Fatty acid metabolism has a close relationship with metabolic syndrome. Saturated very long-chain fatty acid (hexacosanoic acid; C26:0) was recently reported to be associated with cardiovascular risk factors in adults. Methods: Eighty-eight children (47 male, 41 female; average age, 10.9 y) participated in this study. Concentrations of C26:0 in whole blood were measured. Results: Compared with reported concentrations in the whole blood of adults, children had lower C26:0 concentrations, which had a close relationship with abdominal obesity, increased concentrations of low-density lipoprotein cholesterol and high blood pressure. C26:0 concentrations increased with increasing number of risk factors. Conclusions: Elevation of C26:0 concentrations may be one of the metabolic features of children with cardiovascular risk factors.

KW - Abdominal obesity

KW - Childhood obesity

KW - Hexacosanoic acid(C26:0)

KW - Very long-chain fatty acid

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U2 - 10.1016/j.cca.2008.12.013

DO - 10.1016/j.cca.2008.12.013

M3 - Article

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AN - SCOPUS:58549096914

SN - 0009-8981

VL - 401

SP - 141

EP - 143

JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

IS - 1-2

ER -

Concentrations of very long-chain fatty acid in whole blood are associated with cardiovascular risk factors in children

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