TY - JOUR
T1 - Visceral adiposity and high adiponectin levels are associated with the prevalence of pancreatic cystic lesions
AU - Mizuno, Suguru
AU - Nakai, Yousuke
AU - Isayama, Hiroyuki
AU - Yoshikawa, Takeharu
AU - Saito, Kei
AU - Takahara, Naminatsu
AU - Kogure, Hirofumi
AU - Tada, Minoru
AU - Hayashi, Naoto
AU - Koike, Kazuhiko
N1 - Publisher Copyright:
© 2018, Macmillan Publishers Limited, part of Springer Nature.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Objectives: Obesity is increasing in developed countries and is a risk factor for pancreatic cancer (PaC). We previously reported that obesity was associated with pancreatic cystic lesions (PCLs), which are both precursors of, and risk factors for, PaC. In the present study, we further investigated the relationship between visceral adiposity and adiponectin levels and the extent of PCLs. Methods: Individuals who underwent comprehensive health screening at our institution between January 2008 and March 2013 were analyzed. PCLs were diagnosed via magnetic resonance imaging using a 3.0 Tesla system. The volumes of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were measured from computed tomographic volume data. Serum levels of adiponectin were measured using a sandwich enzyme-linked immunosorbent assay. Results: The prevalences of PCLs were 14.2% in males (N = 2683; mean age, 56.4 years) and 16.2% in females (N = 1741; mean age, 57.1 years). The prevalence of PCLs increased gradually as VAT volume increased (P < 0.001). PCLs were more prevalent in individuals with high adiponectin levels (18.7% vs. 13.8%, P = 0.005). VAT volume (odds ratio [OR] for the highest quartiles, 1.52 [1.07–2.16]; P = 0.025) and adiponectin level (OR for the highest quartiles, 1.31 [1.08–1.59]; P = 0.007) but not SAT volume (P = 0.828) was significantly associated with PCLs in multivariate analyses. Conclusions: Visceral adiposity and high adiponectin levels were associated with PCL prevalence. Further work is needed to explore the relationships between visceral adiposity and adiponectin levels, and PCLs and PaC.
AB - Objectives: Obesity is increasing in developed countries and is a risk factor for pancreatic cancer (PaC). We previously reported that obesity was associated with pancreatic cystic lesions (PCLs), which are both precursors of, and risk factors for, PaC. In the present study, we further investigated the relationship between visceral adiposity and adiponectin levels and the extent of PCLs. Methods: Individuals who underwent comprehensive health screening at our institution between January 2008 and March 2013 were analyzed. PCLs were diagnosed via magnetic resonance imaging using a 3.0 Tesla system. The volumes of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were measured from computed tomographic volume data. Serum levels of adiponectin were measured using a sandwich enzyme-linked immunosorbent assay. Results: The prevalences of PCLs were 14.2% in males (N = 2683; mean age, 56.4 years) and 16.2% in females (N = 1741; mean age, 57.1 years). The prevalence of PCLs increased gradually as VAT volume increased (P < 0.001). PCLs were more prevalent in individuals with high adiponectin levels (18.7% vs. 13.8%, P = 0.005). VAT volume (odds ratio [OR] for the highest quartiles, 1.52 [1.07–2.16]; P = 0.025) and adiponectin level (OR for the highest quartiles, 1.31 [1.08–1.59]; P = 0.007) but not SAT volume (P = 0.828) was significantly associated with PCLs in multivariate analyses. Conclusions: Visceral adiposity and high adiponectin levels were associated with PCL prevalence. Further work is needed to explore the relationships between visceral adiposity and adiponectin levels, and PCLs and PaC.
UR - http://www.scopus.com/inward/record.url?scp=85047117726&partnerID=8YFLogxK
U2 - 10.1038/s41366-018-0083-4
DO - 10.1038/s41366-018-0083-4
M3 - Article
C2 - 29777233
AN - SCOPUS:85047117726
SN - 0307-0565
VL - 43
SP - 169
EP - 175
JO - International Journal of Obesity
JF - International Journal of Obesity
IS - 1
ER -
