Transforming growth factor-β as a treatment target in renal diseases

Noboru Fukuda, Yoshiko Tahira, Hiroyuki Matsuda, Koichi Matsumoto

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)


A number of studies have identified transforming growth factor-β (TGF-β) as a critical factor in renal diseases such as glomerulosclerosis and mesangioproliferative glomerulonephritis. TGF-β stimulates proliferation of mesangial cells, production of extracellular matrix components and induces epithelial-mesenchymal transformation in renal tissue, which plays a critical role in the pathogenesis of renal injury. Thus, TGF-β is a treatment target in renal diseases. However, progressive renal diseases cannot be cured with present medical technologies. We have developed ribozymes and a novel gene silencer pyrrole-imidazole polyamide targeted to TGF-β that effectively ameliorate renal injury in hypertensive rats.

Original languageEnglish
Pages (from-to)708-715
Number of pages8
JournalJournal of Nephrology
Issue number6
Publication statusPublished - 2009


  • Chronic kidney disease
  • Epithelial-mesenchymal transformation
  • Extracellular matrix
  • Gene therapy
  • TGF-β


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