Total cholesterol level for assessing pancreatic insufficiency due to chronic pancreatitis

Kenji Hirano, Tomotaka Saito, Suguru Mizuno, Minoru Tada, Naoki Sasahira, Hiroyuki Isayama, Miho Matsukawa, Gyotane Umefune, Dai Akiyama, Kei Saito, Shuhei Kawahata, Naminatsu Takahara, Rie Uchino, Tsuyoshi Hamada, Koji Miyabayashi, Dai Mohri, Takashi Sasaki, Hirofumi Kogure, Natsuyo Yamamoto, Yosuke NakaiKazuhiko Koike

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Background/Aims: To determine the nutritional markers important for assessing the degree of pancreatic insufficiency due to chronic pancreatitis in routine clinical practice. Methods: A total of 137 patients with chronic pancreatitis were followed up for more than 1 year. They were divided into two groups: a pancreatic diabetes mellitus (DM) group, consisting of 47 patients undergoing medical treatment for DM of pancreatic origin, and a nonpancreatic DM group, consisting of 90 other patients (including 86 patients without DM). Serum albumin, prealbumin, total cholesterol, cholinesterase, magnesium, and hemoglobin were compared between the two groups. Results: The total cholesterol was significantly lower in the pancreatic than the nonpancreatic DM group (164 mg/dL vs 183 mg/dL, respectively; p=0.0028). Cholinesterase was significantly lower in the former group (263 U/L vs 291 U/L, respectively; p=0.016). Among the 37 patients with nonalcoholic pancreatitis, there was no difference in the cholinesterase levels between the pancreatic and nonpancreatic (296 U/L vs 304 U/L, respectively; p=0.752) DM groups, although cholesterol levels remained lower in the former (165 mg/dL vs 187 mg/dL, respectively; p=0.052). Conclusions: Cholinesterase levels are possibly affected by concomitant alcoholic liver injury. The total cholesterol level should be considered when assessing pancreatic insufficiency due to chronic pancreatitis.

Original languageEnglish
Pages (from-to)563-568
Number of pages6
JournalGut and Liver
Issue number5
Publication statusPublished - Sept 2014
Externally publishedYes


  • Cholesterol
  • Cholinesterase
  • Chronic pancreatitis
  • Diabetes mellitus
  • Pancreatic exocrine insufficiency


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