TLC-based MS Imaging Analysis of Glycosphingolipids and Glycerin Fatty Acid Esters after 1,2-Dichloroethane Washing

Shoko Matsushita, Takuma Hasegawa, Marina Hiraoka, Aki Hayashi, Yusuke Suzuki

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Matrix-assisted laser desorption/ionization-based mass spectrometry imaging (MSI) of separated lipids on thin-layer chromatography (TLC) plates or followed by blotted hydrophilic polyvinylidene fluoride (PVDF) membranes has become a powerful tool in lipidomic analyses. However, background peaks in MS spectra often cover lipid peaks in a low amount/ionization effect; consequently, only low intensities/resolutions MSI are obtained.

Original languageEnglish
Pages (from-to)1491-1495
Number of pages5
JournalAnalytical Sciences
Volume37
Issue number11
DOIs
Publication statusPublished - 2021

Keywords

  • 1
  • 2-Dichloroethane
  • glycerin fatty acid ester
  • glycosphingolipid
  • mass spectrometry imaging
  • thin-layer chromatography

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