Thromboembolisms in Advanced Pancreatic Cancer: A Retrospective Analysis of 475 Patients

Kazunaga Ishigaki; Yousuke Nakai; Hiroyuki Isayama; Kei Saito; Tsuyoshi Hamada; Naminatsu Takahara; Suguru Mizuno; Dai Mohri; Hirofumi Kogure; Saburo Matsubara; Natsuyo Yamamoto; Minoru Tada; Kazuhiko Koike

doi:10.1097/MPA.0000000000000889

Thromboembolisms in Advanced Pancreatic Cancer: A Retrospective Analysis of 475 Patients

Kazunaga Ishigaki, Yousuke Nakai, Hiroyuki Isayama, Kei Saito, Tsuyoshi Hamada, Naminatsu Takahara, Suguru Mizuno, Dai Mohri, Hirofumi Kogure, Saburo Matsubara, Natsuyo Yamamoto, Minoru Tada, Kazuhiko Koike

The University of Tokyo

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Objectives Pancreatic cancer is reported to be highly associated with thromboembolism (TE). The aim of this analysis is to clarify risk factors for TE and its clinical impact in Japanese patients with pancreatic cancer. Methods Data on consecutive pancreatic cancer patients receiving systemic chemotherapy between August 1999 and July 2015 were retrospectively studied. Both symptomatic and asymptomatic, arterial and venous TEs were included in the analysis. Risk factors for TE development were analyzed using a proportional hazards model with death without TE as a competing risk. The impact of TE on survival was also evaluated using a time-dependent covariate multiple Cox model. Results A total of 475 patients were included in the analysis, and 57 TEs (12%) were identified: 45 venous TEs and 12 arterial TEs. The median time to TE was 169 days and the median survival from TE was 65 days. Liver metastasis was the only significant risk factor for TE (subdistribution hazards ratio, 2.15; P = 0.01), and TE was significantly associated with poor prognosis (hazards ratio, 3.31; P < 0.01). Conclusions Thromboembolism was not uncommon in Japanese patients receiving chemotherapy for advanced pancreatic cancer and was associated with poor prognosis. Liver metastasis was the risk factor for TE.

Original language	English
Pages (from-to)	1069-1075
Number of pages	7
Journal	Pancreas
Volume	46
Issue number	8
DOIs	https://doi.org/10.1097/MPA.0000000000000889
Publication status	Published - 1 Sept 2017
Externally published	Yes

Keywords

Thromboembolism
chemotherapy
liver metastasis
pancreatic cancer
prognosis
risk factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/MPA.0000000000000889

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title = "Thromboembolisms in Advanced Pancreatic Cancer: A Retrospective Analysis of 475 Patients",

abstract = "Objectives Pancreatic cancer is reported to be highly associated with thromboembolism (TE). The aim of this analysis is to clarify risk factors for TE and its clinical impact in Japanese patients with pancreatic cancer. Methods Data on consecutive pancreatic cancer patients receiving systemic chemotherapy between August 1999 and July 2015 were retrospectively studied. Both symptomatic and asymptomatic, arterial and venous TEs were included in the analysis. Risk factors for TE development were analyzed using a proportional hazards model with death without TE as a competing risk. The impact of TE on survival was also evaluated using a time-dependent covariate multiple Cox model. Results A total of 475 patients were included in the analysis, and 57 TEs (12%) were identified: 45 venous TEs and 12 arterial TEs. The median time to TE was 169 days and the median survival from TE was 65 days. Liver metastasis was the only significant risk factor for TE (subdistribution hazards ratio, 2.15; P = 0.01), and TE was significantly associated with poor prognosis (hazards ratio, 3.31; P < 0.01). Conclusions Thromboembolism was not uncommon in Japanese patients receiving chemotherapy for advanced pancreatic cancer and was associated with poor prognosis. Liver metastasis was the risk factor for TE.",

keywords = "Thromboembolism, chemotherapy, liver metastasis, pancreatic cancer, prognosis, risk factors",

author = "Kazunaga Ishigaki and Yousuke Nakai and Hiroyuki Isayama and Kei Saito and Tsuyoshi Hamada and Naminatsu Takahara and Suguru Mizuno and Dai Mohri and Hirofumi Kogure and Saburo Matsubara and Natsuyo Yamamoto and Minoru Tada and Kazuhiko Koike",

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month = sep,

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doi = "10.1097/MPA.0000000000000889",

language = "English",

volume = "46",

pages = "1069--1075",

journal = "Pancreas",

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}

TY - JOUR

T1 - Thromboembolisms in Advanced Pancreatic Cancer

T2 - A Retrospective Analysis of 475 Patients

AU - Ishigaki, Kazunaga

AU - Nakai, Yousuke

AU - Isayama, Hiroyuki

AU - Saito, Kei

AU - Hamada, Tsuyoshi

AU - Takahara, Naminatsu

AU - Mizuno, Suguru

AU - Mohri, Dai

AU - Kogure, Hirofumi

AU - Matsubara, Saburo

AU - Yamamoto, Natsuyo

AU - Tada, Minoru

AU - Koike, Kazuhiko

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Objectives Pancreatic cancer is reported to be highly associated with thromboembolism (TE). The aim of this analysis is to clarify risk factors for TE and its clinical impact in Japanese patients with pancreatic cancer. Methods Data on consecutive pancreatic cancer patients receiving systemic chemotherapy between August 1999 and July 2015 were retrospectively studied. Both symptomatic and asymptomatic, arterial and venous TEs were included in the analysis. Risk factors for TE development were analyzed using a proportional hazards model with death without TE as a competing risk. The impact of TE on survival was also evaluated using a time-dependent covariate multiple Cox model. Results A total of 475 patients were included in the analysis, and 57 TEs (12%) were identified: 45 venous TEs and 12 arterial TEs. The median time to TE was 169 days and the median survival from TE was 65 days. Liver metastasis was the only significant risk factor for TE (subdistribution hazards ratio, 2.15; P = 0.01), and TE was significantly associated with poor prognosis (hazards ratio, 3.31; P < 0.01). Conclusions Thromboembolism was not uncommon in Japanese patients receiving chemotherapy for advanced pancreatic cancer and was associated with poor prognosis. Liver metastasis was the risk factor for TE.

AB - Objectives Pancreatic cancer is reported to be highly associated with thromboembolism (TE). The aim of this analysis is to clarify risk factors for TE and its clinical impact in Japanese patients with pancreatic cancer. Methods Data on consecutive pancreatic cancer patients receiving systemic chemotherapy between August 1999 and July 2015 were retrospectively studied. Both symptomatic and asymptomatic, arterial and venous TEs were included in the analysis. Risk factors for TE development were analyzed using a proportional hazards model with death without TE as a competing risk. The impact of TE on survival was also evaluated using a time-dependent covariate multiple Cox model. Results A total of 475 patients were included in the analysis, and 57 TEs (12%) were identified: 45 venous TEs and 12 arterial TEs. The median time to TE was 169 days and the median survival from TE was 65 days. Liver metastasis was the only significant risk factor for TE (subdistribution hazards ratio, 2.15; P = 0.01), and TE was significantly associated with poor prognosis (hazards ratio, 3.31; P < 0.01). Conclusions Thromboembolism was not uncommon in Japanese patients receiving chemotherapy for advanced pancreatic cancer and was associated with poor prognosis. Liver metastasis was the risk factor for TE.

KW - Thromboembolism

KW - chemotherapy

KW - liver metastasis

KW - pancreatic cancer

KW - prognosis

KW - risk factors

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Thromboembolisms in Advanced Pancreatic Cancer: A Retrospective Analysis of 475 Patients

Abstract

Keywords

UN SDGs

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