The natural history of sporadic non-ampullary duodenal epithelial tumors: Can we wait and see?

Yoshiki Sakaguchi; Yosuke Tsuji; Tetsuo Ushiku; Dai Kubota; Junichi Sato; Miho Obata; Rina Cho; Sayaka Nagao; Nobuyuki Sakuma; Naoki Tamura; Yuko Miura; Kazushi Fukagawa; Daisuke Ohki; Hiroya Mizutani; Chihiro Takeuchi; Yu Takahashi; Chihiro Minatsuki; Keiko Niimi; Nobutake Yamamichi; Kazuhiko Koike

doi:10.1002/deo2.9

The natural history of sporadic non-ampullary duodenal epithelial tumors: Can we wait and see?

Yoshiki Sakaguchi, Yosuke Tsuji, Tetsuo Ushiku, Dai Kubota, Junichi Sato, Miho Obata, Rina Cho, Sayaka Nagao, Nobuyuki Sakuma, Naoki Tamura, Yuko Miura, Kazushi Fukagawa, Daisuke Ohki, Hiroya Mizutani, Chihiro Takeuchi, Yu Takahashi, Chihiro Minatsuki, Keiko Niimi, Nobutake Yamamichi, Kazuhiko Koike

The University of Tokyo

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Objectives: The natural history of sporadic non-ampullary duodenal epithelial tumors (SNADETs) is poorly documented. The aim of this study was to evaluate the history of SNADETs in patients where immediate resection could not be performed. Methods: This is a single-center retrospective study of 86 consecutive cases of SNADETs who did not undergo immediate resection and were followed-up with upper gastrointestinal endoscopy for more than 6 months. Results: During a follow-up period of 36.8 (6.0–613.0) months, macroscopic progression was admitted in eight (9.3%). Of these, the final histology in four was adenocarcinoma, and three cases demonstrated submucosal invasion. Rates of macroscopic progression at 150 months after detection were 11.1%, 16.7%, and 30.0% for SNADETs <5 mm, <10 mm, and ≥10 mm, respectively. Conclusion: The overall risk of SNADETs progressing to invasive cancer is low. However, changes in macroscopic size or shape of SNADETs signify a high risk of progression to invasive cancer.

Original language	English
Article number	e9
Journal	DEN Open
Volume	1
Issue number	1
DOIs	https://doi.org/10.1002/deo2.9
Publication status	Published - Apr 2021
Externally published	Yes

Keywords

natural history
sporadic non-ampullary duodenal epithelial tumor
tumor progression

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/deo2.9

Cite this

Sakaguchi, Y., Tsuji, Y., Ushiku, T., Kubota, D., Sato, J., Obata, M., Cho, R., Nagao, S., Sakuma, N., Tamura, N., Miura, Y., Fukagawa, K., Ohki, D., Mizutani, H., Takeuchi, C., Takahashi, Y., Minatsuki, C., Niimi, K., Yamamichi, N., & Koike, K. (2021). The natural history of sporadic non-ampullary duodenal epithelial tumors: Can we wait and see? DEN Open, 1(1), Article e9. https://doi.org/10.1002/deo2.9

@article{81871aceb4994b6fb02a923adaeb8696,

title = "The natural history of sporadic non-ampullary duodenal epithelial tumors: Can we wait and see?",

abstract = "Objectives: The natural history of sporadic non-ampullary duodenal epithelial tumors (SNADETs) is poorly documented. The aim of this study was to evaluate the history of SNADETs in patients where immediate resection could not be performed. Methods: This is a single-center retrospective study of 86 consecutive cases of SNADETs who did not undergo immediate resection and were followed-up with upper gastrointestinal endoscopy for more than 6 months. Results: During a follow-up period of 36.8 (6.0–613.0) months, macroscopic progression was admitted in eight (9.3%). Of these, the final histology in four was adenocarcinoma, and three cases demonstrated submucosal invasion. Rates of macroscopic progression at 150 months after detection were 11.1%, 16.7%, and 30.0% for SNADETs <5 mm, <10 mm, and ≥10 mm, respectively. Conclusion: The overall risk of SNADETs progressing to invasive cancer is low. However, changes in macroscopic size or shape of SNADETs signify a high risk of progression to invasive cancer.",

keywords = "natural history, sporadic non-ampullary duodenal epithelial tumor, tumor progression",

author = "Yoshiki Sakaguchi and Yosuke Tsuji and Tetsuo Ushiku and Dai Kubota and Junichi Sato and Miho Obata and Rina Cho and Sayaka Nagao and Nobuyuki Sakuma and Naoki Tamura and Yuko Miura and Kazushi Fukagawa and Daisuke Ohki and Hiroya Mizutani and Chihiro Takeuchi and Yu Takahashi and Chihiro Minatsuki and Keiko Niimi and Nobutake Yamamichi and Kazuhiko Koike",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors. DEN Open published by John Wiley & Sons Australia, Ltd on behalf of Japan Gastroenterological Endoscopy Society.",

year = "2021",

month = apr,

doi = "10.1002/deo2.9",

language = "English",

volume = "1",

journal = "DEN Open",

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Sakaguchi, Y, Tsuji, Y, Ushiku, T, Kubota, D, Sato, J, Obata, M, Cho, R, Nagao, S, Sakuma, N, Tamura, N, Miura, Y, Fukagawa, K, Ohki, D, Mizutani, H, Takeuchi, C, Takahashi, Y, Minatsuki, C, Niimi, K, Yamamichi, N & Koike, K 2021, 'The natural history of sporadic non-ampullary duodenal epithelial tumors: Can we wait and see?', DEN Open, vol. 1, no. 1, e9. https://doi.org/10.1002/deo2.9

TY - JOUR

T1 - The natural history of sporadic non-ampullary duodenal epithelial tumors

T2 - Can we wait and see?

AU - Sakaguchi, Yoshiki

AU - Tsuji, Yosuke

AU - Ushiku, Tetsuo

AU - Kubota, Dai

AU - Sato, Junichi

AU - Obata, Miho

AU - Cho, Rina

AU - Nagao, Sayaka

AU - Sakuma, Nobuyuki

AU - Tamura, Naoki

AU - Miura, Yuko

AU - Fukagawa, Kazushi

AU - Ohki, Daisuke

AU - Mizutani, Hiroya

AU - Takeuchi, Chihiro

AU - Takahashi, Yu

AU - Minatsuki, Chihiro

AU - Niimi, Keiko

AU - Yamamichi, Nobutake

AU - Koike, Kazuhiko

PY - 2021/4

Y1 - 2021/4

N2 - Objectives: The natural history of sporadic non-ampullary duodenal epithelial tumors (SNADETs) is poorly documented. The aim of this study was to evaluate the history of SNADETs in patients where immediate resection could not be performed. Methods: This is a single-center retrospective study of 86 consecutive cases of SNADETs who did not undergo immediate resection and were followed-up with upper gastrointestinal endoscopy for more than 6 months. Results: During a follow-up period of 36.8 (6.0–613.0) months, macroscopic progression was admitted in eight (9.3%). Of these, the final histology in four was adenocarcinoma, and three cases demonstrated submucosal invasion. Rates of macroscopic progression at 150 months after detection were 11.1%, 16.7%, and 30.0% for SNADETs <5 mm, <10 mm, and ≥10 mm, respectively. Conclusion: The overall risk of SNADETs progressing to invasive cancer is low. However, changes in macroscopic size or shape of SNADETs signify a high risk of progression to invasive cancer.

AB - Objectives: The natural history of sporadic non-ampullary duodenal epithelial tumors (SNADETs) is poorly documented. The aim of this study was to evaluate the history of SNADETs in patients where immediate resection could not be performed. Methods: This is a single-center retrospective study of 86 consecutive cases of SNADETs who did not undergo immediate resection and were followed-up with upper gastrointestinal endoscopy for more than 6 months. Results: During a follow-up period of 36.8 (6.0–613.0) months, macroscopic progression was admitted in eight (9.3%). Of these, the final histology in four was adenocarcinoma, and three cases demonstrated submucosal invasion. Rates of macroscopic progression at 150 months after detection were 11.1%, 16.7%, and 30.0% for SNADETs <5 mm, <10 mm, and ≥10 mm, respectively. Conclusion: The overall risk of SNADETs progressing to invasive cancer is low. However, changes in macroscopic size or shape of SNADETs signify a high risk of progression to invasive cancer.

KW - natural history

KW - sporadic non-ampullary duodenal epithelial tumor

KW - tumor progression

UR - http://www.scopus.com/inward/record.url?scp=85138815059&partnerID=8YFLogxK

U2 - 10.1002/deo2.9

DO - 10.1002/deo2.9

M3 - Article

AN - SCOPUS:85138815059

SN - 2692-4609

VL - 1

JO - DEN Open

JF - DEN Open

IS - 1

M1 - e9

ER -

The natural history of sporadic non-ampullary duodenal epithelial tumors: Can we wait and see?

Abstract

Keywords

UN SDGs

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