Synopsis of a clinical practice guideline for pancreatic ductal adenocarcinoma with peritoneal dissemination in Japan; Japan Peritoneal Malignancy Study Group

Sohei Satoi, Naminatsu Takahara, Tsutomu Fujii, Hiroyuki Isayama, Suguru Yamada, Yasushi Tsuji, Hideyo Miyato, Hironori Yamaguchi, Tomohisa Yamamoto, Daisuke Hashimoto, So Yamaki, Yousuke Nakai, Kei Saito, Hayato Baba, Toru Watanabe, Shigeto Ishii, Masamichi Hayashi, Keisuke Kurimoto, Hideaki Shimada, Joji Kitayama

Research output: Contribution to journalReview articlepeer-review

7 Citations (Scopus)

Abstract

Patients with pancreatic ductal adenocarcinoma (PDAC) with peritoneal dissemination have a dismal prognosis because discontinuation of systemic chemotherapy is required for massive ascites or poor performance status. The natural history, diagnosis and treatment of PDAC with peritoneal dissemination have not been fully investigated. We systematically reviewed published information on the clinical diagnosis and treatment of PDAC with peritoneal dissemination using the PubMed database (2000-2020) and provided recommendations in response to clinical questions. This guideline was created according to the "Minds Clinical Practice Guideline Development Guide 2017". The literature quality and body of evidence were evaluated with the GRADE System and classified into four levels (“strong”, “medium”, “weak”, “very weak”). The strength of each final recommendation was decided by a vote of committee members based on the GRADE Grid method. These guidelines address three subjects: diagnostic, chemotherapeutic, and surgical approaches. They include nine clinical questions and statements with recommendation strengths, evidence levels, and agreement rates, in addition to one “column”. This is the English synopsis of the 2021 Japanese clinical practice guideline for PDAC with peritoneal dissemination. It summarizes the clinical evidence for the diagnosis and treatment of PDAC with peritoneal dissemination and provides future perspectives.

Original languageEnglish
Pages (from-to)600-608
Number of pages9
JournalJournal of Hepato-Biliary-Pancreatic Sciences
Volume29
Issue number6
DOIs
Publication statusPublished - Jun 2022
Externally publishedYes

Keywords

  • guideline
  • pancreatic ductal adenocarcinoma
  • peritoneal dissemination

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