Survival days of patients with metastatic spinal tumors of lung cancer requiring surgery: a prospective multicenter study

Takuya Takahashi; Takashi Hirai; Yuki Shiratani; Akinobu Suzuki; Kenichiro Kakutani; Satoshi Kato; Hiroyuki Tominaga; Hirokazu Inoue; Hirokatsu Sawada; Norihiko Takegami; Kazuo Nakanishi; Hideaki Nakajima; Masayuki Ishihara; Tsutomu Oshigiri; Toru Funayama; Takuya Iimura; Shinji Tanishima; Hiroaki Nakashima; Daisuke Yamabe; Ko Hashimoto; Koji Uotani; Masahiro Funaba; Narihito Nagoshi; Kazu Kobayakawa; Toshitaka Yoshii; Kazuyuki Watanabe; Toshio Nakamae; Takashi Kaito; Gen Inoue; Shiro Imagama; Kota Watanabe; Takeo Furuya

doi:10.1038/s41598-025-08775-9

Survival days of patients with metastatic spinal tumors of lung cancer requiring surgery: a prospective multicenter study

Takuya Takahashi, Takashi Hirai, Yuki Shiratani, Akinobu Suzuki, Kenichiro Kakutani, Satoshi Kato, Hiroyuki Tominaga, Hirokazu Inoue, Hirokatsu Sawada, Norihiko Takegami, Kazuo Nakanishi, Hideaki Nakajima, Masayuki Ishihara, Tsutomu Oshigiri, Toru Funayama, Takuya Iimura, Shinji Tanishima, Hiroaki Nakashima, Daisuke Yamabe, Ko HashimotoKoji Uotani, Masahiro Funaba, Narihito Nagoshi, Kazu Kobayakawa, Toshitaka Yoshii, Kazuyuki Watanabe, Toshio Nakamae, Takashi Kaito, Gen Inoue, Shiro Imagama, Kota Watanabe, Takeo Furuya

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Surgery for metastatic spinal tumors has improved postoperative activities of daily living. A few studies reported on prognostic factors assessed in large multicenter prospective studies for metastatic spinal tumors of lung cancer origin. This study aimed to determine preoperative prognostic factors in patients undergoing surgery for metastatic spinal tumors associated with lung cancer. This prospective registry study included 74 patients diagnosed and operated with metastatic spine tumors derived from lung cancer in 39 high-volume cancer centers. We examined the postoperative survival period and the preoperative factors related to postoperative survival time. We conducted univariate and multivariate Cox regression analyses to determine preoperative prognostic factors. The mean postoperative survival period was 343 days. Multivariate Cox regression analysis revealed a higher feeding score of vitality index, indications for molecularly targeted therapy, and a higher mobility score of Barthel index as independent factors associated with postoperative survival time in metastatic spinal tumors derived from lung cancer. Patients with indications for molecular-targeted therapy and good vitality exhibited longer survival. These results may help in surgical selection for patients with metastatic spinal tumors derived from lung cancer.

Original language	English
Article number	24117
Journal	Scientific Reports
Volume	15
Issue number	1
DOIs	https://doi.org/10.1038/s41598-025-08775-9
Publication status	Published - Dec 2025

Keywords

Barthel index
Lung cancer
Metastatic spinal tumor
Molecularly targeted therapy
Postoperative survival period
Vitality index

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41598-025-08775-9

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Takahashi, T., Hirai, T., Shiratani, Y., Suzuki, A., Kakutani, K., Kato, S., Tominaga, H., Inoue, H., Sawada, H., Takegami, N., Nakanishi, K., Nakajima, H., Ishihara, M., Oshigiri, T., Funayama, T., Iimura, T., Tanishima, S., Nakashima, H., Yamabe, D., ... Furuya, T. (2025). Survival days of patients with metastatic spinal tumors of lung cancer requiring surgery: a prospective multicenter study. Scientific Reports, 15(1), Article 24117. https://doi.org/10.1038/s41598-025-08775-9

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title = "Survival days of patients with metastatic spinal tumors of lung cancer requiring surgery: a prospective multicenter study",

abstract = "Surgery for metastatic spinal tumors has improved postoperative activities of daily living. A few studies reported on prognostic factors assessed in large multicenter prospective studies for metastatic spinal tumors of lung cancer origin. This study aimed to determine preoperative prognostic factors in patients undergoing surgery for metastatic spinal tumors associated with lung cancer. This prospective registry study included 74 patients diagnosed and operated with metastatic spine tumors derived from lung cancer in 39 high-volume cancer centers. We examined the postoperative survival period and the preoperative factors related to postoperative survival time. We conducted univariate and multivariate Cox regression analyses to determine preoperative prognostic factors. The mean postoperative survival period was 343 days. Multivariate Cox regression analysis revealed a higher feeding score of vitality index, indications for molecularly targeted therapy, and a higher mobility score of Barthel index as independent factors associated with postoperative survival time in metastatic spinal tumors derived from lung cancer. Patients with indications for molecular-targeted therapy and good vitality exhibited longer survival. These results may help in surgical selection for patients with metastatic spinal tumors derived from lung cancer.",

keywords = "Barthel index, Lung cancer, Metastatic spinal tumor, Molecularly targeted therapy, Postoperative survival period, Vitality index",

author = "Takuya Takahashi and Takashi Hirai and Yuki Shiratani and Akinobu Suzuki and Kenichiro Kakutani and Satoshi Kato and Hiroyuki Tominaga and Hirokazu Inoue and Hirokatsu Sawada and Norihiko Takegami and Kazuo Nakanishi and Hideaki Nakajima and Masayuki Ishihara and Tsutomu Oshigiri and Toru Funayama and Takuya Iimura and Shinji Tanishima and Hiroaki Nakashima and Daisuke Yamabe and Ko Hashimoto and Koji Uotani and Masahiro Funaba and Narihito Nagoshi and Kazu Kobayakawa and Toshitaka Yoshii and Kazuyuki Watanabe and Toshio Nakamae and Takashi Kaito and Gen Inoue and Shiro Imagama and Kota Watanabe and Takeo Furuya",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2025.",

year = "2025",

month = dec,

doi = "10.1038/s41598-025-08775-9",

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volume = "15",

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Takahashi, T, Hirai, T, Shiratani, Y, Suzuki, A, Kakutani, K, Kato, S, Tominaga, H, Inoue, H, Sawada, H, Takegami, N, Nakanishi, K, Nakajima, H, Ishihara, M, Oshigiri, T, Funayama, T, Iimura, T, Tanishima, S, Nakashima, H, Yamabe, D, Hashimoto, K, Uotani, K, Funaba, M, Nagoshi, N, Kobayakawa, K, Yoshii, T, Watanabe, K, Nakamae, T, Kaito, T, Inoue, G, Imagama, S, Watanabe, K & Furuya, T 2025, 'Survival days of patients with metastatic spinal tumors of lung cancer requiring surgery: a prospective multicenter study', Scientific Reports, vol. 15, no. 1, 24117. https://doi.org/10.1038/s41598-025-08775-9

TY - JOUR

T1 - Survival days of patients with metastatic spinal tumors of lung cancer requiring surgery

T2 - a prospective multicenter study

AU - Takahashi, Takuya

AU - Hirai, Takashi

AU - Shiratani, Yuki

AU - Suzuki, Akinobu

AU - Kakutani, Kenichiro

AU - Kato, Satoshi

AU - Tominaga, Hiroyuki

AU - Inoue, Hirokazu

AU - Sawada, Hirokatsu

AU - Takegami, Norihiko

AU - Nakanishi, Kazuo

AU - Nakajima, Hideaki

AU - Ishihara, Masayuki

AU - Oshigiri, Tsutomu

AU - Funayama, Toru

AU - Iimura, Takuya

AU - Tanishima, Shinji

AU - Nakashima, Hiroaki

AU - Yamabe, Daisuke

AU - Hashimoto, Ko

AU - Uotani, Koji

AU - Funaba, Masahiro

AU - Nagoshi, Narihito

AU - Kobayakawa, Kazu

AU - Yoshii, Toshitaka

AU - Watanabe, Kazuyuki

AU - Nakamae, Toshio

AU - Kaito, Takashi

AU - Inoue, Gen

AU - Imagama, Shiro

AU - Watanabe, Kota

AU - Furuya, Takeo

PY - 2025/12

Y1 - 2025/12

N2 - Surgery for metastatic spinal tumors has improved postoperative activities of daily living. A few studies reported on prognostic factors assessed in large multicenter prospective studies for metastatic spinal tumors of lung cancer origin. This study aimed to determine preoperative prognostic factors in patients undergoing surgery for metastatic spinal tumors associated with lung cancer. This prospective registry study included 74 patients diagnosed and operated with metastatic spine tumors derived from lung cancer in 39 high-volume cancer centers. We examined the postoperative survival period and the preoperative factors related to postoperative survival time. We conducted univariate and multivariate Cox regression analyses to determine preoperative prognostic factors. The mean postoperative survival period was 343 days. Multivariate Cox regression analysis revealed a higher feeding score of vitality index, indications for molecularly targeted therapy, and a higher mobility score of Barthel index as independent factors associated with postoperative survival time in metastatic spinal tumors derived from lung cancer. Patients with indications for molecular-targeted therapy and good vitality exhibited longer survival. These results may help in surgical selection for patients with metastatic spinal tumors derived from lung cancer.

AB - Surgery for metastatic spinal tumors has improved postoperative activities of daily living. A few studies reported on prognostic factors assessed in large multicenter prospective studies for metastatic spinal tumors of lung cancer origin. This study aimed to determine preoperative prognostic factors in patients undergoing surgery for metastatic spinal tumors associated with lung cancer. This prospective registry study included 74 patients diagnosed and operated with metastatic spine tumors derived from lung cancer in 39 high-volume cancer centers. We examined the postoperative survival period and the preoperative factors related to postoperative survival time. We conducted univariate and multivariate Cox regression analyses to determine preoperative prognostic factors. The mean postoperative survival period was 343 days. Multivariate Cox regression analysis revealed a higher feeding score of vitality index, indications for molecularly targeted therapy, and a higher mobility score of Barthel index as independent factors associated with postoperative survival time in metastatic spinal tumors derived from lung cancer. Patients with indications for molecular-targeted therapy and good vitality exhibited longer survival. These results may help in surgical selection for patients with metastatic spinal tumors derived from lung cancer.

KW - Barthel index

KW - Lung cancer

KW - Metastatic spinal tumor

KW - Molecularly targeted therapy

KW - Postoperative survival period

KW - Vitality index

UR - https://www.scopus.com/pages/publications/105010131972

U2 - 10.1038/s41598-025-08775-9

DO - 10.1038/s41598-025-08775-9

M3 - Article

C2 - 40619496

AN - SCOPUS:105010131972

SN - 2045-2322

VL - 15

JO - Scientific Reports

JF - Scientific Reports

IS - 1

M1 - 24117

ER -

Survival days of patients with metastatic spinal tumors of lung cancer requiring surgery: a prospective multicenter study

Abstract

Keywords

UN SDGs

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