Superinfection of hepatitis A virus in hepatocytes infected with hepatitis B virus

Nan Nwe Win; Tatsuo Kanda; Masahiro Ogawa; Shingo Nakamoto; Yuki Haga; Reina Sasaki; Masato Nakamura; Shuang Wu; Naoki Matsumoto; Shunichi Matsuoka; Naoya Kato; Hiroshi Shirasawa; Osamu Yokosuka; Hiroaki Okamoto; Mitsuhiko Moriyama

doi:10.7150/ijms.32795

Superinfection of hepatitis A virus in hepatocytes infected with hepatitis B virus

Nan Nwe Win, Tatsuo Kanda, Masahiro Ogawa, Shingo Nakamoto, Yuki Haga, Reina Sasaki, Masato Nakamura, Shuang Wu, Naoki Matsumoto, Shunichi Matsuoka, Naoya Kato, Hiroshi Shirasawa, Osamu Yokosuka, Hiroaki Okamoto, Mitsuhiko Moriyama

School of Medicine

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Hepatitis A virus (HAV) infection is a major cause of acute hepatitis including acute liver failure. Hepatitis B infection (HBV) occurs worldwide, with the highest rates in Asian and African countries, and there are several reports that HAV infection may have a more severe clinical course in patients with chronic HBV infection. We previously demonstrated that Japanese miso extracts have inhibitory effects on HAV replication. In the present study, we examined the replication of HAV and HBV in a hepatocyte superinfection model and the inhibitory effects of Japanese miso extracts on both viruses. According to the results, HAV infection inhibited HBV replication in superinfected hepatocytes, and Japanese rice-koji miso extracts had inhibitory effects on HAV replication. Our findings provide useful information for clinicians in managing HAV infection in patients with chronic HBV infection.

Original language	English
Pages (from-to)	1366-1370
Number of pages	5
Journal	International Journal of Medical Sciences
Volume	16
Issue number	10
DOIs	https://doi.org/10.7150/ijms.32795
Publication status	Published - 2019

Keywords

Dual infection
HAV
HBV
Miso extracts
Rice koji

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.7150/ijms.32795

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Win, N. N., Kanda, T., Ogawa, M., Nakamoto, S., Haga, Y., Sasaki, R., Nakamura, M., Wu, S., Matsumoto, N., Matsuoka, S., Kato, N., Shirasawa, H., Yokosuka, O., Okamoto, H., & Moriyama, M. (2019). Superinfection of hepatitis A virus in hepatocytes infected with hepatitis B virus. International Journal of Medical Sciences, 16(10), 1366-1370. https://doi.org/10.7150/ijms.32795

@article{4fef208da643430c94b9b5a427fe791a,

title = "Superinfection of hepatitis A virus in hepatocytes infected with hepatitis B virus",

abstract = "Hepatitis A virus (HAV) infection is a major cause of acute hepatitis including acute liver failure. Hepatitis B infection (HBV) occurs worldwide, with the highest rates in Asian and African countries, and there are several reports that HAV infection may have a more severe clinical course in patients with chronic HBV infection. We previously demonstrated that Japanese miso extracts have inhibitory effects on HAV replication. In the present study, we examined the replication of HAV and HBV in a hepatocyte superinfection model and the inhibitory effects of Japanese miso extracts on both viruses. According to the results, HAV infection inhibited HBV replication in superinfected hepatocytes, and Japanese rice-koji miso extracts had inhibitory effects on HAV replication. Our findings provide useful information for clinicians in managing HAV infection in patients with chronic HBV infection.",

keywords = "Dual infection, HAV, HBV, Miso extracts, Rice koji",

author = "Win, {Nan Nwe} and Tatsuo Kanda and Masahiro Ogawa and Shingo Nakamoto and Yuki Haga and Reina Sasaki and Masato Nakamura and Shuang Wu and Naoki Matsumoto and Shunichi Matsuoka and Naoya Kato and Hiroshi Shirasawa and Osamu Yokosuka and Hiroaki Okamoto and Mitsuhiko Moriyama",

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year = "2019",

doi = "10.7150/ijms.32795",

language = "English",

volume = "16",

pages = "1366--1370",

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Win, NN, Kanda, T, Ogawa, M, Nakamoto, S, Haga, Y, Sasaki, R, Nakamura, M, Wu, S, Matsumoto, N, Matsuoka, S, Kato, N, Shirasawa, H, Yokosuka, O, Okamoto, H & Moriyama, M 2019, 'Superinfection of hepatitis A virus in hepatocytes infected with hepatitis B virus', International Journal of Medical Sciences, vol. 16, no. 10, pp. 1366-1370. https://doi.org/10.7150/ijms.32795

TY - JOUR

T1 - Superinfection of hepatitis A virus in hepatocytes infected with hepatitis B virus

AU - Win, Nan Nwe

AU - Kanda, Tatsuo

AU - Ogawa, Masahiro

AU - Nakamoto, Shingo

AU - Haga, Yuki

AU - Sasaki, Reina

AU - Nakamura, Masato

AU - Wu, Shuang

AU - Matsumoto, Naoki

AU - Matsuoka, Shunichi

AU - Kato, Naoya

AU - Shirasawa, Hiroshi

AU - Yokosuka, Osamu

AU - Okamoto, Hiroaki

AU - Moriyama, Mitsuhiko

PY - 2019

Y1 - 2019

N2 - Hepatitis A virus (HAV) infection is a major cause of acute hepatitis including acute liver failure. Hepatitis B infection (HBV) occurs worldwide, with the highest rates in Asian and African countries, and there are several reports that HAV infection may have a more severe clinical course in patients with chronic HBV infection. We previously demonstrated that Japanese miso extracts have inhibitory effects on HAV replication. In the present study, we examined the replication of HAV and HBV in a hepatocyte superinfection model and the inhibitory effects of Japanese miso extracts on both viruses. According to the results, HAV infection inhibited HBV replication in superinfected hepatocytes, and Japanese rice-koji miso extracts had inhibitory effects on HAV replication. Our findings provide useful information for clinicians in managing HAV infection in patients with chronic HBV infection.

AB - Hepatitis A virus (HAV) infection is a major cause of acute hepatitis including acute liver failure. Hepatitis B infection (HBV) occurs worldwide, with the highest rates in Asian and African countries, and there are several reports that HAV infection may have a more severe clinical course in patients with chronic HBV infection. We previously demonstrated that Japanese miso extracts have inhibitory effects on HAV replication. In the present study, we examined the replication of HAV and HBV in a hepatocyte superinfection model and the inhibitory effects of Japanese miso extracts on both viruses. According to the results, HAV infection inhibited HBV replication in superinfected hepatocytes, and Japanese rice-koji miso extracts had inhibitory effects on HAV replication. Our findings provide useful information for clinicians in managing HAV infection in patients with chronic HBV infection.

KW - Dual infection

KW - HAV

KW - HBV

KW - Miso extracts

KW - Rice koji

UR - http://www.scopus.com/inward/record.url?scp=85073746417&partnerID=8YFLogxK

U2 - 10.7150/ijms.32795

DO - 10.7150/ijms.32795

M3 - Article

C2 - 31692913

AN - SCOPUS:85073746417

SN - 1449-1907

VL - 16

SP - 1366

EP - 1370

JO - International Journal of Medical Sciences

JF - International Journal of Medical Sciences

IS - 10

ER -

Superinfection of hepatitis A virus in hepatocytes infected with hepatitis B virus

Abstract

Keywords

UN SDGs

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