State of homeobox A10 expression as a putative prognostic marker for oral squamous cell carcinoma

Masanobu Yamatoji; Atsushi Kasamatsu; Yukio Yamano; Kentaro Sakuma; Kenji Ogoshi; Manabu Iyoda; Keiji Shinozuka; Katsunori Ogawara; Yuichi Takiguchi; Masashi Shiiba; Hideki Tanzawa; Katsuhiro Uzawa

doi:10.3892/or-00000606

State of homeobox A10 expression as a putative prognostic marker for oral squamous cell carcinoma

Masanobu Yamatoji, Atsushi Kasamatsu, Yukio Yamano, Kentaro Sakuma, Kenji Ogoshi, Manabu Iyoda, Keiji Shinozuka, Katsunori Ogawara, Yuichi Takiguchi, Masashi Shiiba, Hideki Tanzawa, Katsuhiro Uzawa

Chiba University

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Homeobox (HOX) A10, the regulator of embryonic morphogenesis and differentiation, is aberrantly expressed in several cancer types. Our previous study using microarray technology showed that significant up-regulation of HOXA10 occurs in oral squamous cell carcinoma (OSCC)-derived cell lines compared to human normal oral keratinocytes (HNOKs). The aim of the current study was to examine the status of HOXA10 mRNA and protein expression in OSCC-derived cell lines and human primary OSCCs. HOXA10 mRNA was up-regulated in six OSCC-derived cell lines compared with HNOKs and in primary OSCCs by using real-time quantitative reverse transcriptasepolymerase chain reaction. Immunohistochemistry data indicated that HOXA10 protein expression levels were consistent with mRNA expression status in OSCC-derived cell lines and primary OSCCs. Furthermore, HOXA10 expression status was correlated with the TNM stage (P<0.05). These results indicate that HOXA10 expression could contribute to cancer progression and prognosis and that HOXA10 may be a potential diagnostic marker and a therapeutic target for OSCCs.

Original language	English
Pages (from-to)	61-67
Number of pages	7
Journal	Oncology Reports
Volume	23
Issue number	1
DOIs	https://doi.org/10.3892/or-00000606
Publication status	Published - 2010
Externally published	Yes

Keywords

Homeobox a10
Immunohistochemistry
Oral squamous cell carcinoma
Quantitative reverse transcriptase-polymerase chain reaction

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3892/or-00000606

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title = "State of homeobox A10 expression as a putative prognostic marker for oral squamous cell carcinoma",

abstract = "Homeobox (HOX) A10, the regulator of embryonic morphogenesis and differentiation, is aberrantly expressed in several cancer types. Our previous study using microarray technology showed that significant up-regulation of HOXA10 occurs in oral squamous cell carcinoma (OSCC)-derived cell lines compared to human normal oral keratinocytes (HNOKs). The aim of the current study was to examine the status of HOXA10 mRNA and protein expression in OSCC-derived cell lines and human primary OSCCs. HOXA10 mRNA was up-regulated in six OSCC-derived cell lines compared with HNOKs and in primary OSCCs by using real-time quantitative reverse transcriptasepolymerase chain reaction. Immunohistochemistry data indicated that HOXA10 protein expression levels were consistent with mRNA expression status in OSCC-derived cell lines and primary OSCCs. Furthermore, HOXA10 expression status was correlated with the TNM stage (P<0.05). These results indicate that HOXA10 expression could contribute to cancer progression and prognosis and that HOXA10 may be a potential diagnostic marker and a therapeutic target for OSCCs.",

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author = "Masanobu Yamatoji and Atsushi Kasamatsu and Yukio Yamano and Kentaro Sakuma and Kenji Ogoshi and Manabu Iyoda and Keiji Shinozuka and Katsunori Ogawara and Yuichi Takiguchi and Masashi Shiiba and Hideki Tanzawa and Katsuhiro Uzawa",

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TY - JOUR

T1 - State of homeobox A10 expression as a putative prognostic marker for oral squamous cell carcinoma

AU - Yamatoji, Masanobu

AU - Kasamatsu, Atsushi

AU - Yamano, Yukio

AU - Sakuma, Kentaro

AU - Ogoshi, Kenji

AU - Iyoda, Manabu

AU - Shinozuka, Keiji

AU - Ogawara, Katsunori

AU - Takiguchi, Yuichi

AU - Shiiba, Masashi

AU - Tanzawa, Hideki

AU - Uzawa, Katsuhiro

PY - 2010

Y1 - 2010

N2 - Homeobox (HOX) A10, the regulator of embryonic morphogenesis and differentiation, is aberrantly expressed in several cancer types. Our previous study using microarray technology showed that significant up-regulation of HOXA10 occurs in oral squamous cell carcinoma (OSCC)-derived cell lines compared to human normal oral keratinocytes (HNOKs). The aim of the current study was to examine the status of HOXA10 mRNA and protein expression in OSCC-derived cell lines and human primary OSCCs. HOXA10 mRNA was up-regulated in six OSCC-derived cell lines compared with HNOKs and in primary OSCCs by using real-time quantitative reverse transcriptasepolymerase chain reaction. Immunohistochemistry data indicated that HOXA10 protein expression levels were consistent with mRNA expression status in OSCC-derived cell lines and primary OSCCs. Furthermore, HOXA10 expression status was correlated with the TNM stage (P<0.05). These results indicate that HOXA10 expression could contribute to cancer progression and prognosis and that HOXA10 may be a potential diagnostic marker and a therapeutic target for OSCCs.

AB - Homeobox (HOX) A10, the regulator of embryonic morphogenesis and differentiation, is aberrantly expressed in several cancer types. Our previous study using microarray technology showed that significant up-regulation of HOXA10 occurs in oral squamous cell carcinoma (OSCC)-derived cell lines compared to human normal oral keratinocytes (HNOKs). The aim of the current study was to examine the status of HOXA10 mRNA and protein expression in OSCC-derived cell lines and human primary OSCCs. HOXA10 mRNA was up-regulated in six OSCC-derived cell lines compared with HNOKs and in primary OSCCs by using real-time quantitative reverse transcriptasepolymerase chain reaction. Immunohistochemistry data indicated that HOXA10 protein expression levels were consistent with mRNA expression status in OSCC-derived cell lines and primary OSCCs. Furthermore, HOXA10 expression status was correlated with the TNM stage (P<0.05). These results indicate that HOXA10 expression could contribute to cancer progression and prognosis and that HOXA10 may be a potential diagnostic marker and a therapeutic target for OSCCs.

KW - Homeobox a10

KW - Immunohistochemistry

KW - Oral squamous cell carcinoma

KW - Quantitative reverse transcriptase-polymerase chain reaction

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DO - 10.3892/or-00000606

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SN - 1021-335X

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EP - 67

JO - Oncology Reports

JF - Oncology Reports

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ER -

State of homeobox A10 expression as a putative prognostic marker for oral squamous cell carcinoma

Abstract

Keywords

UN SDGs

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