TY - JOUR
T1 - Salivary alpha-amylase activity is increased by noxious stimuli under general anesthesia
AU - Hirose, Noriya
AU - Matsui, Miki
AU - Itagaki, Masumi
AU - Shimizu, Nao
AU - Mizoguchi, Mizuki
AU - Kitano, Hisataka
AU - Chang, Emily
AU - Yamagata, Kanako
AU - Suzuki, Takahiro
N1 - Publisher Copyright:
© 2025 Asian AOMS, ASOMP, JSOP, JSOMS, JSOM, and JAMI
PY - 2026/3
Y1 - 2026/3
N2 - Objective: This study evaluated changes in salivary alpha-amylase activity (sAA) before and after orotracheal intubation (TI) and precordial skin incision (SI) to investigate whether sAA was increased by noxious stimuli while under general anesthesia. Methods: sAA was measured before and after TI (study A: randomized double-blind test) and SI (study B; single-arm observational test) in 50 and 30 patients, respectively. Study A patients were divided into 2 groups of 25 each according to administration of 1.0 (LF group) or 2.0 µg/kg of fentanyl (HF group) during anesthesia induction. sAA was measured at four points, with study A measurements performed before anesthesia induction, immediately before TI, and at 3 and 6 min after TI, while study B measurements were performed before anesthesia induction, immediately before SI, and at 3 and 6 min after SI, respectively. Results: sAA significantly increased at 3 min after TI, and at 3 and 6 min after SI compared to before the procedure (P < 0.01). In study A, the observed sAA levels at 3 and 6 min after TI in the HF group were significantly lower than those observed in the LF group (P < 0.01). Conclusions: sAA increased after TI and SI. sAA measurements might be an ancillary indicator for sympathetic tone associated with noxious stimuli under general anesthesia.
AB - Objective: This study evaluated changes in salivary alpha-amylase activity (sAA) before and after orotracheal intubation (TI) and precordial skin incision (SI) to investigate whether sAA was increased by noxious stimuli while under general anesthesia. Methods: sAA was measured before and after TI (study A: randomized double-blind test) and SI (study B; single-arm observational test) in 50 and 30 patients, respectively. Study A patients were divided into 2 groups of 25 each according to administration of 1.0 (LF group) or 2.0 µg/kg of fentanyl (HF group) during anesthesia induction. sAA was measured at four points, with study A measurements performed before anesthesia induction, immediately before TI, and at 3 and 6 min after TI, while study B measurements were performed before anesthesia induction, immediately before SI, and at 3 and 6 min after SI, respectively. Results: sAA significantly increased at 3 min after TI, and at 3 and 6 min after SI compared to before the procedure (P < 0.01). In study A, the observed sAA levels at 3 and 6 min after TI in the HF group were significantly lower than those observed in the LF group (P < 0.01). Conclusions: sAA increased after TI and SI. sAA measurements might be an ancillary indicator for sympathetic tone associated with noxious stimuli under general anesthesia.
KW - General anesthesia
KW - Noxious stimuli
KW - Salivary alpha-amylase activity
UR - https://www.scopus.com/pages/publications/105015507188
U2 - 10.1016/j.ajoms.2025.09.003
DO - 10.1016/j.ajoms.2025.09.003
M3 - Article
AN - SCOPUS:105015507188
SN - 2212-5558
VL - 38
SP - 201
EP - 208
JO - Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
JF - Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
IS - 2
ER -