Roles of peptidyl prolyl isomerase Pin1 in viral propagation

Machi Kanna; Yusuke Nakatsu; Takeshi Yamamotoya; Jeffrey Encinas; Hisanaka Ito; Takayoshi Okabe; Tomoichiro Asano; Takemasa Sakaguchi

doi:10.3389/fcell.2022.1005325

Roles of peptidyl prolyl isomerase Pin1 in viral propagation

Machi Kanna, Yusuke Nakatsu, Takeshi Yamamotoya, Jeffrey Encinas, Hisanaka Ito, Takayoshi Okabe, Tomoichiro Asano, Takemasa Sakaguchi

Research output: Contribution to journal › Review article › peer-review

6 Citations (Scopus)

Abstract

Peptidyl-prolyl isomerase (PPIase) is a unique enzyme that promotes cis-trans isomerization of a proline residue of a target protein. Peptidyl-prolyl cis-trans isomerase NIMA (never in mitosis A)-interacting 1 (Pin1) is a PPIase that binds to the pSer/pThr-Pro motif of target proteins and isomerizes their prolines. Pin1 has been reported to be involved in cancer development, obesity, aging, and Alzheimer’s disease and has been shown to promote the growth of several viruses including SARS-CoV-2. Pin1 enhances the efficiency of viral infection by promoting uncoating and integration of the human immunodeficiency virus. It has also been shown that Pin1 interacts with hepatitis B virus proteins and participates in viral replication. Furthermore, Pin1 promotes not only viral proliferation but also the progression of virus-induced tumorigenesis. In this review, we focus on the effects of Pin1 on the proliferation of various viruses and discuss the underlying molecular mechanisms.

Original language	English
Article number	1005325
Journal	Frontiers in Cell and Developmental Biology
Volume	10
DOIs	https://doi.org/10.3389/fcell.2022.1005325
Publication status	Published - 25 Oct 2022
Externally published	Yes

Keywords

hepatitis B virus
human immunodeficiency virus
Pin1
PPIases
virus

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3389/fcell.2022.1005325

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title = "Roles of peptidyl prolyl isomerase Pin1 in viral propagation",

abstract = "Peptidyl-prolyl isomerase (PPIase) is a unique enzyme that promotes cis-trans isomerization of a proline residue of a target protein. Peptidyl-prolyl cis-trans isomerase NIMA (never in mitosis A)-interacting 1 (Pin1) is a PPIase that binds to the pSer/pThr-Pro motif of target proteins and isomerizes their prolines. Pin1 has been reported to be involved in cancer development, obesity, aging, and Alzheimer{\textquoteright}s disease and has been shown to promote the growth of several viruses including SARS-CoV-2. Pin1 enhances the efficiency of viral infection by promoting uncoating and integration of the human immunodeficiency virus. It has also been shown that Pin1 interacts with hepatitis B virus proteins and participates in viral replication. Furthermore, Pin1 promotes not only viral proliferation but also the progression of virus-induced tumorigenesis. In this review, we focus on the effects of Pin1 on the proliferation of various viruses and discuss the underlying molecular mechanisms.",

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author = "Machi Kanna and Yusuke Nakatsu and Takeshi Yamamotoya and Jeffrey Encinas and Hisanaka Ito and Takayoshi Okabe and Tomoichiro Asano and Takemasa Sakaguchi",

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year = "2022",

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doi = "10.3389/fcell.2022.1005325",

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T1 - Roles of peptidyl prolyl isomerase Pin1 in viral propagation

AU - Kanna, Machi

AU - Nakatsu, Yusuke

AU - Yamamotoya, Takeshi

AU - Encinas, Jeffrey

AU - Ito, Hisanaka

AU - Okabe, Takayoshi

AU - Asano, Tomoichiro

AU - Sakaguchi, Takemasa

PY - 2022/10/25

Y1 - 2022/10/25

N2 - Peptidyl-prolyl isomerase (PPIase) is a unique enzyme that promotes cis-trans isomerization of a proline residue of a target protein. Peptidyl-prolyl cis-trans isomerase NIMA (never in mitosis A)-interacting 1 (Pin1) is a PPIase that binds to the pSer/pThr-Pro motif of target proteins and isomerizes their prolines. Pin1 has been reported to be involved in cancer development, obesity, aging, and Alzheimer’s disease and has been shown to promote the growth of several viruses including SARS-CoV-2. Pin1 enhances the efficiency of viral infection by promoting uncoating and integration of the human immunodeficiency virus. It has also been shown that Pin1 interacts with hepatitis B virus proteins and participates in viral replication. Furthermore, Pin1 promotes not only viral proliferation but also the progression of virus-induced tumorigenesis. In this review, we focus on the effects of Pin1 on the proliferation of various viruses and discuss the underlying molecular mechanisms.

AB - Peptidyl-prolyl isomerase (PPIase) is a unique enzyme that promotes cis-trans isomerization of a proline residue of a target protein. Peptidyl-prolyl cis-trans isomerase NIMA (never in mitosis A)-interacting 1 (Pin1) is a PPIase that binds to the pSer/pThr-Pro motif of target proteins and isomerizes their prolines. Pin1 has been reported to be involved in cancer development, obesity, aging, and Alzheimer’s disease and has been shown to promote the growth of several viruses including SARS-CoV-2. Pin1 enhances the efficiency of viral infection by promoting uncoating and integration of the human immunodeficiency virus. It has also been shown that Pin1 interacts with hepatitis B virus proteins and participates in viral replication. Furthermore, Pin1 promotes not only viral proliferation but also the progression of virus-induced tumorigenesis. In this review, we focus on the effects of Pin1 on the proliferation of various viruses and discuss the underlying molecular mechanisms.

KW - hepatitis B virus

KW - human immunodeficiency virus

KW - Pin1

KW - PPIases

KW - virus

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U2 - 10.3389/fcell.2022.1005325

DO - 10.3389/fcell.2022.1005325

M3 - Review article

AN - SCOPUS:85141373506

SN - 2296-634X

VL - 10

JO - Frontiers in Cell and Developmental Biology

JF - Frontiers in Cell and Developmental Biology

M1 - 1005325

ER -

Roles of peptidyl prolyl isomerase Pin1 in viral propagation

Abstract

Keywords

UN SDGs

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