Restriction of SARS-CoV-2 replication in the human placenta

Kazuhide Takada; Sayaka Shimodai-Yamada; Mayumi Suzuki; Quang Duy Trinh; Chika Takano; Kaori Kawakami; Mikiko Asai-Sato; Atsushi Komatsu; Aya Okahashi; Nobuhiko Nagano; Toshiya Misawa; Kyohei Yamaguchi; Tadaki Suzuki; Kei Kawana; Ichiro Morioka; Hideto Yamada; Satoshi Hayakawa; Hiroyuki Hao; Shihoko Komine-Aizawa

doi:10.1016/j.placenta.2022.07.010

Restriction of SARS-CoV-2 replication in the human placenta

Kazuhide Takada, Sayaka Shimodai-Yamada, Mayumi Suzuki, Quang Duy Trinh, Chika Takano, Kaori Kawakami, Mikiko Asai-Sato, Atsushi Komatsu, Aya Okahashi, Nobuhiko Nagano, Toshiya Misawa, Kyohei Yamaguchi, Tadaki Suzuki, Kei Kawana, Ichiro Morioka, Hideto Yamada, Satoshi Hayakawa, Hiroyuki Hao, Shihoko Komine-Aizawa

School of Medicine

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Although SARS-CoV-2 can infect human placental tissue, vertical transmission is rare. Therefore, the placenta may function as a barrier to inhibit viral transmission to the foetus, though the mechanisms remain unclear. In this study, we confirmed the presence of the SARS-CoV-2 genome in human placental tissue by in situ hybridization with antisense probes targeting the spike protein; tissue staining was much lower when using sense probes for the spike protein. To the best of our knowledge, this is the first evidence directly indicating inefficient viral replication in the SARS-CoV-2-infected placenta. Additional studies are required to reveal the detailed mechanisms.

Original language	English
Pages (from-to)	73-76
Number of pages	4
Journal	Placenta
Volume	127
DOIs	https://doi.org/10.1016/j.placenta.2022.07.010
Publication status	Published - Sept 2022

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Takada, K., Shimodai-Yamada, S., Suzuki, M., Trinh, Q. D., Takano, C., Kawakami, K., Asai-Sato, M., Komatsu, A., Okahashi, A., Nagano, N., Misawa, T., Yamaguchi, K., Suzuki, T., Kawana, K., Morioka, I., Yamada, H., Hayakawa, S., Hao, H., & Komine-Aizawa, S. (2022). Restriction of SARS-CoV-2 replication in the human placenta. Placenta, 127, 73-76. https://doi.org/10.1016/j.placenta.2022.07.010

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title = "Restriction of SARS-CoV-2 replication in the human placenta",

abstract = "Although SARS-CoV-2 can infect human placental tissue, vertical transmission is rare. Therefore, the placenta may function as a barrier to inhibit viral transmission to the foetus, though the mechanisms remain unclear. In this study, we confirmed the presence of the SARS-CoV-2 genome in human placental tissue by in situ hybridization with antisense probes targeting the spike protein; tissue staining was much lower when using sense probes for the spike protein. To the best of our knowledge, this is the first evidence directly indicating inefficient viral replication in the SARS-CoV-2-infected placenta. Additional studies are required to reveal the detailed mechanisms.",

author = "Kazuhide Takada and Sayaka Shimodai-Yamada and Mayumi Suzuki and Trinh, {Quang Duy} and Chika Takano and Kaori Kawakami and Mikiko Asai-Sato and Atsushi Komatsu and Aya Okahashi and Nobuhiko Nagano and Toshiya Misawa and Kyohei Yamaguchi and Tadaki Suzuki and Kei Kawana and Ichiro Morioka and Hideto Yamada and Satoshi Hayakawa and Hiroyuki Hao and Shihoko Komine-Aizawa",

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year = "2022",

month = sep,

doi = "10.1016/j.placenta.2022.07.010",

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Takada, K, Shimodai-Yamada, S, Suzuki, M, Trinh, QD, Takano, C, Kawakami, K, Asai-Sato, M, Komatsu, A, Okahashi, A, Nagano, N, Misawa, T, Yamaguchi, K, Suzuki, T, Kawana, K, Morioka, I, Yamada, H, Hayakawa, S, Hao, H & Komine-Aizawa, S 2022, 'Restriction of SARS-CoV-2 replication in the human placenta', Placenta, vol. 127, pp. 73-76. https://doi.org/10.1016/j.placenta.2022.07.010

TY - JOUR

T1 - Restriction of SARS-CoV-2 replication in the human placenta

AU - Takada, Kazuhide

AU - Shimodai-Yamada, Sayaka

AU - Suzuki, Mayumi

AU - Trinh, Quang Duy

AU - Takano, Chika

AU - Kawakami, Kaori

AU - Asai-Sato, Mikiko

AU - Komatsu, Atsushi

AU - Okahashi, Aya

AU - Nagano, Nobuhiko

AU - Misawa, Toshiya

AU - Yamaguchi, Kyohei

AU - Suzuki, Tadaki

AU - Kawana, Kei

AU - Morioka, Ichiro

AU - Yamada, Hideto

AU - Hayakawa, Satoshi

AU - Hao, Hiroyuki

AU - Komine-Aizawa, Shihoko

PY - 2022/9

Y1 - 2022/9

N2 - Although SARS-CoV-2 can infect human placental tissue, vertical transmission is rare. Therefore, the placenta may function as a barrier to inhibit viral transmission to the foetus, though the mechanisms remain unclear. In this study, we confirmed the presence of the SARS-CoV-2 genome in human placental tissue by in situ hybridization with antisense probes targeting the spike protein; tissue staining was much lower when using sense probes for the spike protein. To the best of our knowledge, this is the first evidence directly indicating inefficient viral replication in the SARS-CoV-2-infected placenta. Additional studies are required to reveal the detailed mechanisms.

AB - Although SARS-CoV-2 can infect human placental tissue, vertical transmission is rare. Therefore, the placenta may function as a barrier to inhibit viral transmission to the foetus, though the mechanisms remain unclear. In this study, we confirmed the presence of the SARS-CoV-2 genome in human placental tissue by in situ hybridization with antisense probes targeting the spike protein; tissue staining was much lower when using sense probes for the spike protein. To the best of our knowledge, this is the first evidence directly indicating inefficient viral replication in the SARS-CoV-2-infected placenta. Additional studies are required to reveal the detailed mechanisms.

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AN - SCOPUS:85135936301

SN - 0143-4004

VL - 127

SP - 73

EP - 76

JO - Placenta

JF - Placenta

ER -

Restriction of SARS-CoV-2 replication in the human placenta

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