REM sleep behavior disorder predisposed by neuroleptic malignant syndrome: a case report

Michiko Konno; Takahiro Suzuki; Tadashi Kanamori; Ryuji Furihata; Hiromi Yokose; Hideyuki Kubo; Mayumi Akiyama; Masahiro Suzuki; Makoto Uchiyama

doi:10.1007/s41105-018-0184-4

REM sleep behavior disorder predisposed by neuroleptic malignant syndrome: a case report

Michiko Konno
, Takahiro Suzuki
, Tadashi Kanamori
, Ryuji Furihata
, Hiromi Yokose
, Hideyuki Kubo
, Mayumi Akiyama
, Masahiro Suzuki
, Makoto Uchiyama

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

A 44-year-old man was confirmed by polysomnography to have rapid eye movement (REM) sleep behavior disorder (RBD) following recovery from haloperidol- and risperidone-induced neuroleptic malignant syndrome (NMS). RBD symptoms persisted for 30 days. Subsequently, no clinical symptoms or polysomnographic findings of RBD have been observed for 3 years. RBD is reported to be associated with Parkinson’s disease and dementia with Lewy bodies, which involve brainstem dopaminergic hypofunction. However, no reports have documented RBD due to drug-induced dopaminergic hypofunction. This appears to be the first observation of RBD in relation to pharmacological dopaminergic dysfunction.

Original language	English
Pages (from-to)	155-157
Number of pages	3
Journal	Sleep and Biological Rhythms
Volume	17
Issue number	1
DOIs	https://doi.org/10.1007/s41105-018-0184-4
Publication status	Published - 22 Jan 2019

Keywords

Neuroleptic malignant syndrome
REM sleep behavior disorder
REM sleep without muscle atonia

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10.1007/s41105-018-0184-4

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title = "REM sleep behavior disorder predisposed by neuroleptic malignant syndrome: a case report",

abstract = "A 44-year-old man was confirmed by polysomnography to have rapid eye movement (REM) sleep behavior disorder (RBD) following recovery from haloperidol- and risperidone-induced neuroleptic malignant syndrome (NMS). RBD symptoms persisted for 30 days. Subsequently, no clinical symptoms or polysomnographic findings of RBD have been observed for 3 years. RBD is reported to be associated with Parkinson{\textquoteright}s disease and dementia with Lewy bodies, which involve brainstem dopaminergic hypofunction. However, no reports have documented RBD due to drug-induced dopaminergic hypofunction. This appears to be the first observation of RBD in relation to pharmacological dopaminergic dysfunction.",

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T1 - REM sleep behavior disorder predisposed by neuroleptic malignant syndrome

T2 - a case report

AU - Konno, Michiko

AU - Suzuki, Takahiro

AU - Kanamori, Tadashi

AU - Furihata, Ryuji

AU - Yokose, Hiromi

AU - Kubo, Hideyuki

AU - Akiyama, Mayumi

AU - Suzuki, Masahiro

AU - Uchiyama, Makoto

PY - 2019/1/22

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N2 - A 44-year-old man was confirmed by polysomnography to have rapid eye movement (REM) sleep behavior disorder (RBD) following recovery from haloperidol- and risperidone-induced neuroleptic malignant syndrome (NMS). RBD symptoms persisted for 30 days. Subsequently, no clinical symptoms or polysomnographic findings of RBD have been observed for 3 years. RBD is reported to be associated with Parkinson’s disease and dementia with Lewy bodies, which involve brainstem dopaminergic hypofunction. However, no reports have documented RBD due to drug-induced dopaminergic hypofunction. This appears to be the first observation of RBD in relation to pharmacological dopaminergic dysfunction.

AB - A 44-year-old man was confirmed by polysomnography to have rapid eye movement (REM) sleep behavior disorder (RBD) following recovery from haloperidol- and risperidone-induced neuroleptic malignant syndrome (NMS). RBD symptoms persisted for 30 days. Subsequently, no clinical symptoms or polysomnographic findings of RBD have been observed for 3 years. RBD is reported to be associated with Parkinson’s disease and dementia with Lewy bodies, which involve brainstem dopaminergic hypofunction. However, no reports have documented RBD due to drug-induced dopaminergic hypofunction. This appears to be the first observation of RBD in relation to pharmacological dopaminergic dysfunction.

KW - Neuroleptic malignant syndrome

KW - REM sleep behavior disorder

KW - REM sleep without muscle atonia

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REM sleep behavior disorder predisposed by neuroleptic malignant syndrome: a case report

Abstract

Keywords

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