Relationship Between Patient-Friendly Audiovisual Systems and MRI Contrast Agent to Adverse Reactions

Keisuke Nitta, Koji Matsumoto, Hajime Yokota, Taisuke Murata, Yoshitada Masuda, Takashi Uno

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Background: Patient-friendly audiovisual (AV) systems in head MRI examinations can potentially reduce patient anxiety and contrast-enhanced MRI (CE-MRI) adverse reactions to gadolinium. Purpose: To evaluate whether a patient-friendly AV system reduces the rate of adverse reactions to gadolinium-based contrast agents. Study Type: Retrospective. Population: Four thousand eight hundred thirty-two outpatients (2462 female) attending for clinical CE-MRI studies. (Gadoteridol: 1971, Meglumine gadoterate: 2733, Gadobutrol: 128.). Field Strength/Sequence: Routine CE-MRI of head and neck using a 1.5 T or 3 T scanner with or without a patient-friendly AV system. Assessment: One thousand one hundred fifty-nine patients were scanned on MRI machines equipped with patient-friendly AV systems (AV group) and 3673 on MRI machines without AV systems (control group). Adverse reaction rate and symptoms were reviewed by referring to the system database and electronic medical records and compared between the two groups. Adverse reactions were defined as physiological reactions, such as vomiting and allergic-like reactions, such as urticaria, occurring within 1 hour of contrast injection. We compare patient backgrounds, adverse reaction rate, adverse reactions symptoms and the severity between the two groups. Statistical Tests: Adverse reaction rate with and without a patient-friendly AV system were compared using Fisher's exact test. The relationship between patient-friendly AV systems and the occurrence of adverse reactions was evaluated with logistic regression. Statistical significance was set at P < 0.05. Results: Of the 4832 patients enrolled, 65 (1.35%) experienced adverse reactions. The most common adverse reactions in both groups were urticaria and pruritus. Adverse reaction rate was significantly lower in the AV group than in the control group (0.7% vs. 1.6%). No significant difference was observed in the severity (P = 1.000) of adverse reactions and symptoms (allergic-like reaction: P = 0.08, physiologic reaction: P = 1.000) between the two groups. Data Conclusion: The patient-friendly AV system significantly reduce adverse reaction occurrence to gadolinium-based contrast agents. Evidence Level: 4. Technical Efficacy: Stage 1.

Original languageEnglish
Pages (from-to)2013-2020
Number of pages8
JournalJournal of Magnetic Resonance Imaging
Issue number6
Publication statusPublished - Jun 2024
Externally publishedYes


  • adverse reactions
  • anxiety
  • gadolinium-based contrast agents
  • patient-friendly audiovisual system


Dive into the research topics of 'Relationship Between Patient-Friendly Audiovisual Systems and MRI Contrast Agent to Adverse Reactions'. Together they form a unique fingerprint.

Cite this