TY - JOUR
T1 - Phenotypic analysis of hepatic T lymphocytes in a dog with chronic hepatitis
AU - Sakai, Manabu
AU - Otani, Isao
AU - Ishigaki, Kumiko
AU - Edamura, Kazuya
AU - Takahashi, Tomoko
AU - Koie, Hiroshi
AU - Yamaya, Yoshiki
AU - Watari, Toshihiro
AU - Shibuya, Hisashi
AU - Sato, Tsuneo
AU - Kanayama, Biichi
AU - Tokuriki, Mikihiko
AU - Hasegawa, Atsuhiko
PY - 2006/11
Y1 - 2006/11
N2 - We evaluated hepatic T lymphocyte phenotypes in a dog with chronic hepatitis. Before treatment, numerous CD3+ lymphocytes were demonstrated in the liver, and the ratio of CD4+/CD8+ was remarkably high (2.96; reference range, 0.33 ± 0.12). After treatment, CD3+ lymphocyte infiltration in the liver was reduced, and the ratio of CD4+/CD8+ decreased to 0.31. Therefore, hepatic T lymphocytes, especially CD4+ lymphocytes, might play a central role in the pathogenesis of this dog with chronic hepatitis.
AB - We evaluated hepatic T lymphocyte phenotypes in a dog with chronic hepatitis. Before treatment, numerous CD3+ lymphocytes were demonstrated in the liver, and the ratio of CD4+/CD8+ was remarkably high (2.96; reference range, 0.33 ± 0.12). After treatment, CD3+ lymphocyte infiltration in the liver was reduced, and the ratio of CD4+/CD8+ decreased to 0.31. Therefore, hepatic T lymphocytes, especially CD4+ lymphocytes, might play a central role in the pathogenesis of this dog with chronic hepatitis.
KW - Canine chronic hepatitis
KW - Lymphocyte
KW - Phenotype
UR - http://www.scopus.com/inward/record.url?scp=33845416858&partnerID=8YFLogxK
U2 - 10.1292/jvms.68.1219
DO - 10.1292/jvms.68.1219
M3 - Article
C2 - 17146184
AN - SCOPUS:33845416858
SN - 0916-7250
VL - 68
SP - 1219
EP - 1221
JO - Journal of Veterinary Medical Science
JF - Journal of Veterinary Medical Science
IS - 11
ER -
