Phenotypic analysis of hepatic T lymphocytes in a dog with chronic hepatitis

Manabu Sakai, Isao Otani, Kumiko Ishigaki, Kazuya Edamura, Tomoko Takahashi, Hiroshi Koie, Yoshiki Yamaya, Toshihiro Watari, Hisashi Shibuya, Tsuneo Sato, Biichi Kanayama, Mikihiko Tokuriki, Atsuhiko Hasegawa

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


We evaluated hepatic T lymphocyte phenotypes in a dog with chronic hepatitis. Before treatment, numerous CD3+ lymphocytes were demonstrated in the liver, and the ratio of CD4+/CD8+ was remarkably high (2.96; reference range, 0.33 ± 0.12). After treatment, CD3+ lymphocyte infiltration in the liver was reduced, and the ratio of CD4+/CD8+ decreased to 0.31. Therefore, hepatic T lymphocytes, especially CD4+ lymphocytes, might play a central role in the pathogenesis of this dog with chronic hepatitis.

Original languageEnglish
Pages (from-to)1219-1221
Number of pages3
JournalJournal of Veterinary Medical Science
Issue number11
Publication statusPublished - Nov 2006


  • Canine chronic hepatitis
  • Lymphocyte
  • Phenotype


Dive into the research topics of 'Phenotypic analysis of hepatic T lymphocytes in a dog with chronic hepatitis'. Together they form a unique fingerprint.

Cite this