TY - JOUR
T1 - Performing the ABC Method Twice for Gastric Cancer Risk Stratification
T2 - A Retrospective Study Based on Data from a Large-Scale Screening Facility
AU - Mizutani, Satoru
AU - Takahashi, Yu
AU - Shimamoto, Takeshi
AU - Nakagawa, Hideki
AU - Hisada, Hiroyuki
AU - Oshio, Kaori
AU - Kubota, Dai
AU - Mizutani, Hiroya
AU - Ohki, Daisuke
AU - Sakaguchi, Yoshiki
AU - Yakabi, Seiichi
AU - Niimi, Keiko
AU - Kakushima, Naomi
AU - Tsuji, Yosuke
AU - Wada, Ryoichi
AU - Yamamichi, Nobutake
AU - Fujishiro, Mitsuhiro
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/4
Y1 - 2023/4
N2 - The ABC method is a classification method used for stratifying the risk of gastric cancer. However, whether the ABC method should be performed only once or multiple times throughout an individual’s lifetime remains unclear. Therefore, this study aimed to analyze whether performing ABC screening twice in a lifetime is useful. We retrospectively analyzed the data of individuals who participated in health checkups in 2010 and 2015. We collected data on patient characteristics, pepsinogen levels, anti-Helicobacter pylori antibody titers, and the presence of gastric cancer. Overall, 7129 participants without a history of H. pylori eradication were included in this study. The participants’ average age in 2010 was 48.4 ± 8.3 years, and 58.1% were male. In addition, 11 and 20 cases of new H. pylori infection (0.15%) and spontaneous eradication (0.28%), respectively, were recorded. No significant difference was found in the incidence of gastric cancer between participants who underwent the ABC method once and those who underwent it twice (Group A: 0.16% vs. 0.16%; Group B: 0.47% vs. 0.39%; and Group C + D: 1.97% vs. 1.82%). Therefore, performing the ABC method twice, 5 years apart, does not significantly improve gastric cancer risk stratification.
AB - The ABC method is a classification method used for stratifying the risk of gastric cancer. However, whether the ABC method should be performed only once or multiple times throughout an individual’s lifetime remains unclear. Therefore, this study aimed to analyze whether performing ABC screening twice in a lifetime is useful. We retrospectively analyzed the data of individuals who participated in health checkups in 2010 and 2015. We collected data on patient characteristics, pepsinogen levels, anti-Helicobacter pylori antibody titers, and the presence of gastric cancer. Overall, 7129 participants without a history of H. pylori eradication were included in this study. The participants’ average age in 2010 was 48.4 ± 8.3 years, and 58.1% were male. In addition, 11 and 20 cases of new H. pylori infection (0.15%) and spontaneous eradication (0.28%), respectively, were recorded. No significant difference was found in the incidence of gastric cancer between participants who underwent the ABC method once and those who underwent it twice (Group A: 0.16% vs. 0.16%; Group B: 0.47% vs. 0.39%; and Group C + D: 1.97% vs. 1.82%). Therefore, performing the ABC method twice, 5 years apart, does not significantly improve gastric cancer risk stratification.
KW - ABC method
KW - gastric cancer
KW - H. pylori
KW - pepsinogen
KW - risk stratification
UR - http://www.scopus.com/inward/record.url?scp=85152582804&partnerID=8YFLogxK
U2 - 10.3390/diagnostics13071284
DO - 10.3390/diagnostics13071284
M3 - Article
AN - SCOPUS:85152582804
SN - 2075-4418
VL - 13
JO - Diagnostics
JF - Diagnostics
IS - 7
M1 - 1284
ER -
