Orofacial Neuropathic Pain-Basic Research and Their Clinical Relevancies

Masamichi Shinoda, Yoshiki Imamura, Yoshinori Hayashi, Noboru Noma, Akiko Okada-Ogawa, Suzuro Hitomi, Koichi Iwata

Research output: Contribution to journalReview articlepeer-review

18 Citations (Scopus)

Abstract

Trigeminal nerve injury is known to cause severe persistent pain in the orofacial region. This pain is difficult to diagnose and treat. Recently, many animal studies have reported that rewiring of the peripheral and central nervous systems, non-neuronal cell activation, and up- and down-regulation of various molecules in non-neuronal cells are involved in the development of this pain following trigeminal nerve injury. However, there are many unknown mechanisms underlying the persistent orofacial pain associated with trigeminal nerve injury. In this review, we address recent animal data regarding the involvement of various molecules in the communication of neuronal and non-neuronal cells and examine the possible involvement of ascending pathways in processing pathological orofacial pain. We also address the clinical observations of persistent orofacial pain associated with trigeminal nerve injury and clinical approaches to their diagnosis and treatment.

Original languageEnglish
Article number691396
JournalFrontiers in Molecular Neuroscience
Volume14
DOIs
Publication statusPublished - 6 Jul 2021

Keywords

  • craniofacial pain
  • oral diagnosis
  • treatment
  • trigeminal ganglion
  • trigeminal nerve injury
  • trigeminal spinal subnucleus caudalis

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