TY - JOUR
T1 - Obesity Is an Independent Risk Factor for Hepatocellular Carcinoma Development in Chronic Hepatitis C Patients
AU - Ohki, Takamasa
AU - Tateishi, Ryosuke
AU - Sato, Takahisa
AU - Masuzaki, Ryota
AU - Imamura, Jun
AU - Goto, Tadashi
AU - Yamashiki, Noriyo
AU - Yoshida, Hideo
AU - Kanai, Fumihiko
AU - Kato, Naoya
AU - Shiina, Shuichiro
AU - Yoshida, Haruhiko
AU - Kawabe, Takao
AU - Omata, Masao
PY - 2008/4
Y1 - 2008/4
N2 - Background & Aims: It is not fully elucidated whether obesity enhances hepatocarcinogenesis in patients with chronic hepatitis C. The aim of this study was to investigate the relationship between body weight and risk of hepatocarcinogenesis in chronic hepatitis C patients. Methods: We enrolled 1431 patients with chronic hepatitis C who visited our liver clinic between 1994 and 2004, excluding those with hepatocellular carcinoma (HCC) at their visit or with a previous history of HCC. They were divided into 4 groups according to body mass index (BMI): underweight (≤18.5 kg/m2, N = 112); normal (18.5 to less than 25 kg/m2, N = 1023); overweight (25 to less than 30 kg/m2, N = 265); and obese (>30 kg/m2, N = 31). We assessed the impact of obesity on the hepatocarcinogenesis adjusted by multivariate Cox proportional hazard regression with other risk factors found significant in univariate analysis. Results: During the follow-up period (mean, 6.1 y), HCC developed in 340 patients, showing cumulative incidence rates of 10.5%, 19.7%, and 36.8% at 3, 5, and 10 years, respectively. The incidence differed significantly among the BMI groups (P = .007). Adjusting for other significant factors, overweight and obesity were shown to be an independent risk factor of HCC, with a hazard ratio of 1.86 (95% confidence interval, 1.09-3.16; P = .022) and 3.10 (95% confidence interval, 1.41-6.81; P = .005) as compared with the underweight patients. Conclusions: The risk of HCC in patients with chronic hepatitis C increases in proportion to BMI in a wide range of its values, from underweight to obese.
AB - Background & Aims: It is not fully elucidated whether obesity enhances hepatocarcinogenesis in patients with chronic hepatitis C. The aim of this study was to investigate the relationship between body weight and risk of hepatocarcinogenesis in chronic hepatitis C patients. Methods: We enrolled 1431 patients with chronic hepatitis C who visited our liver clinic between 1994 and 2004, excluding those with hepatocellular carcinoma (HCC) at their visit or with a previous history of HCC. They were divided into 4 groups according to body mass index (BMI): underweight (≤18.5 kg/m2, N = 112); normal (18.5 to less than 25 kg/m2, N = 1023); overweight (25 to less than 30 kg/m2, N = 265); and obese (>30 kg/m2, N = 31). We assessed the impact of obesity on the hepatocarcinogenesis adjusted by multivariate Cox proportional hazard regression with other risk factors found significant in univariate analysis. Results: During the follow-up period (mean, 6.1 y), HCC developed in 340 patients, showing cumulative incidence rates of 10.5%, 19.7%, and 36.8% at 3, 5, and 10 years, respectively. The incidence differed significantly among the BMI groups (P = .007). Adjusting for other significant factors, overweight and obesity were shown to be an independent risk factor of HCC, with a hazard ratio of 1.86 (95% confidence interval, 1.09-3.16; P = .022) and 3.10 (95% confidence interval, 1.41-6.81; P = .005) as compared with the underweight patients. Conclusions: The risk of HCC in patients with chronic hepatitis C increases in proportion to BMI in a wide range of its values, from underweight to obese.
UR - http://www.scopus.com/inward/record.url?scp=41149156032&partnerID=8YFLogxK
U2 - 10.1016/j.cgh.2008.02.012
DO - 10.1016/j.cgh.2008.02.012
M3 - Article
C2 - 18387499
AN - SCOPUS:41149156032
SN - 1542-3565
VL - 6
SP - 459
EP - 464
JO - Clinical Gastroenterology and Hepatology
JF - Clinical Gastroenterology and Hepatology
IS - 4
ER -
