TY - JOUR
T1 - Nongestational Ovarian Choriocarcinoma with Precocious Puberty in a 7-Year-Old Girl
T2 - A Rare Case Report
AU - Ono, Kako
AU - Hoshi, Reina
AU - Hirano, Takayuki
AU - Watanabe, Yosuke
AU - Goto, Shumpei
AU - Hosokawa, Takashi
AU - Uehara, Shuichiro
N1 - Publisher Copyright:
© 2025 The Authors
PY - 2025
Y1 - 2025
N2 - Background: Nongestational ovarian choriocarcinoma (NGOC) is extremely rare, particularly in the pediatric population. Few case reports have discussed NGOC with precocious puberty and mentioned both tumor markers (β-human chorionic gonadotropin [hCG], alpha-fetoprotein, CA125) and the dynamics of gonadotropic and gonadal hormones. Case: A 7-year-old girl presented with early puberty and an abdominal mass. Laboratory tests revealed elevated estradiol, β-hCG, and CA125 levels, with suppressed luteinizing hormone and follicle-stimulating hormone. She was diagnosed with ovarian choriocarcinoma and precocious puberty. Following tumor resection, her hormone levels normalized, and symptoms resolved. Conclusion: Pediatric ovarian choriocarcinomas are rare and may present with precocious puberty. Comprehensive endocrine evaluation, including serum hormone assays, is essential for diagnosis. Hormonal profiles in pediatric patients may differ from those in adults, with estradiol levels often being markedly elevated compared to age-specific reference ranges, and progesterone levels being relatively low.
AB - Background: Nongestational ovarian choriocarcinoma (NGOC) is extremely rare, particularly in the pediatric population. Few case reports have discussed NGOC with precocious puberty and mentioned both tumor markers (β-human chorionic gonadotropin [hCG], alpha-fetoprotein, CA125) and the dynamics of gonadotropic and gonadal hormones. Case: A 7-year-old girl presented with early puberty and an abdominal mass. Laboratory tests revealed elevated estradiol, β-hCG, and CA125 levels, with suppressed luteinizing hormone and follicle-stimulating hormone. She was diagnosed with ovarian choriocarcinoma and precocious puberty. Following tumor resection, her hormone levels normalized, and symptoms resolved. Conclusion: Pediatric ovarian choriocarcinomas are rare and may present with precocious puberty. Comprehensive endocrine evaluation, including serum hormone assays, is essential for diagnosis. Hormonal profiles in pediatric patients may differ from those in adults, with estradiol levels often being markedly elevated compared to age-specific reference ranges, and progesterone levels being relatively low.
KW - Estradiol
KW - Gonadotropin-independent precocious puberty
KW - Nongestational ovarian choriocarcinoma
KW - Pediatric
KW - Progesterone
KW - β-hCG
UR - http://www.scopus.com/inward/record.url?scp=105000609867&partnerID=8YFLogxK
U2 - 10.1016/j.jpag.2025.02.007
DO - 10.1016/j.jpag.2025.02.007
M3 - Article
C2 - 40020991
AN - SCOPUS:105000609867
SN - 1083-3188
JO - Journal of Pediatric and Adolescent Gynecology
JF - Journal of Pediatric and Adolescent Gynecology
ER -