Motion-frozen myocardial perfusion SPECT improves detection of coronary artery disease in obese patients

Yasuyuki Suzuki; Piotr J. Slomka; Arik Wolak; Muneo Ohba; Shoji Suzuki; De Yang Ling; Guido Germano; Daniel S. Berman

doi:10.2967/jnumed.108.050997

Motion-frozen myocardial perfusion SPECT improves detection of coronary artery disease in obese patients

Yasuyuki Suzuki, Piotr J. Slomka, Arik Wolak, Muneo Ohba, Shoji Suzuki, De Yang Ling, Guido Germano, Daniel S. Berman

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

In this study, we compared the diagnostic performance of the standard SPECT with motion-frozen (MF) myocardial perfusion SPECT (MPS) in obese patients. Methods: A total of 90 consecutive obese patients (body mass index, 30.1-46.8, average, 34.3 6 3.6; age, 63 6 12 y; 30% women) underwent standard supine rest ²⁰¹Tl/stress ^99mTc dual-isotope gated MPS and cardiac catheterization within 3mo. MF images were obtained by nonlinear warping of cardiac phases to the end-diastolic position. Total perfusion deficit (TPD) was obtained for summed (S-TPD) and motion-frozen (MF-TPD) datasets with sex-specific standard and MF normal limits. Results: The area under the receiver-operating-characteristic (ROC) curve for detection of coronary artery disease (CAD) by MF-TPD was significantly larger than that for S-TPD (0.93 ± 0.25 vs. 0.88 ± 0.32, P < 0.05). MF-TPD had higher specificity (77% vs. 55%, P < 0.05) and accuracy (89% vs. 80%, P < 0.05) than did S-TPD. Conclusion: MF processing of MPS improves CAD detection in obese patients.

Original language	English
Pages (from-to)	1075-1079
Number of pages	5
Journal	Journal of Nuclear Medicine
Volume	49
Issue number	7
DOIs	https://doi.org/10.2967/jnumed.108.050997
Publication status	Published - 1 Jul 2008
Externally published	Yes

Keywords

Coronary artery disease
Gated SPECT
Image registration
Image warping
Motion correction
Myocardial perfusion

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10.2967/jnumed.108.050997

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@article{eb90f72e4795442bb7c955da04d62c99,

title = "Motion-frozen myocardial perfusion SPECT improves detection of coronary artery disease in obese patients",

abstract = "In this study, we compared the diagnostic performance of the standard SPECT with motion-frozen (MF) myocardial perfusion SPECT (MPS) in obese patients. Methods: A total of 90 consecutive obese patients (body mass index, 30.1-46.8, average, 34.3 6 3.6; age, 63 6 12 y; 30\% women) underwent standard supine rest 201Tl/stress 99mTc dual-isotope gated MPS and cardiac catheterization within 3mo. MF images were obtained by nonlinear warping of cardiac phases to the end-diastolic position. Total perfusion deficit (TPD) was obtained for summed (S-TPD) and motion-frozen (MF-TPD) datasets with sex-specific standard and MF normal limits. Results: The area under the receiver-operating-characteristic (ROC) curve for detection of coronary artery disease (CAD) by MF-TPD was significantly larger than that for S-TPD (0.93 ± 0.25 vs. 0.88 ± 0.32, P < 0.05). MF-TPD had higher specificity (77\% vs. 55\%, P < 0.05) and accuracy (89\% vs. 80\%, P < 0.05) than did S-TPD. Conclusion: MF processing of MPS improves CAD detection in obese patients.",

keywords = "Coronary artery disease, Gated SPECT, Image registration, Image warping, Motion correction, Myocardial perfusion",

author = "Yasuyuki Suzuki and Slomka, \{Piotr J.\} and Arik Wolak and Muneo Ohba and Shoji Suzuki and Ling, \{De Yang\} and Guido Germano and Berman, \{Daniel S.\}",

year = "2008",

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doi = "10.2967/jnumed.108.050997",

language = "English",

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T1 - Motion-frozen myocardial perfusion SPECT improves detection of coronary artery disease in obese patients

AU - Suzuki, Yasuyuki

AU - Slomka, Piotr J.

AU - Wolak, Arik

AU - Ohba, Muneo

AU - Suzuki, Shoji

AU - Ling, De Yang

AU - Germano, Guido

AU - Berman, Daniel S.

PY - 2008/7/1

Y1 - 2008/7/1

N2 - In this study, we compared the diagnostic performance of the standard SPECT with motion-frozen (MF) myocardial perfusion SPECT (MPS) in obese patients. Methods: A total of 90 consecutive obese patients (body mass index, 30.1-46.8, average, 34.3 6 3.6; age, 63 6 12 y; 30% women) underwent standard supine rest 201Tl/stress 99mTc dual-isotope gated MPS and cardiac catheterization within 3mo. MF images were obtained by nonlinear warping of cardiac phases to the end-diastolic position. Total perfusion deficit (TPD) was obtained for summed (S-TPD) and motion-frozen (MF-TPD) datasets with sex-specific standard and MF normal limits. Results: The area under the receiver-operating-characteristic (ROC) curve for detection of coronary artery disease (CAD) by MF-TPD was significantly larger than that for S-TPD (0.93 ± 0.25 vs. 0.88 ± 0.32, P < 0.05). MF-TPD had higher specificity (77% vs. 55%, P < 0.05) and accuracy (89% vs. 80%, P < 0.05) than did S-TPD. Conclusion: MF processing of MPS improves CAD detection in obese patients.

AB - In this study, we compared the diagnostic performance of the standard SPECT with motion-frozen (MF) myocardial perfusion SPECT (MPS) in obese patients. Methods: A total of 90 consecutive obese patients (body mass index, 30.1-46.8, average, 34.3 6 3.6; age, 63 6 12 y; 30% women) underwent standard supine rest 201Tl/stress 99mTc dual-isotope gated MPS and cardiac catheterization within 3mo. MF images were obtained by nonlinear warping of cardiac phases to the end-diastolic position. Total perfusion deficit (TPD) was obtained for summed (S-TPD) and motion-frozen (MF-TPD) datasets with sex-specific standard and MF normal limits. Results: The area under the receiver-operating-characteristic (ROC) curve for detection of coronary artery disease (CAD) by MF-TPD was significantly larger than that for S-TPD (0.93 ± 0.25 vs. 0.88 ± 0.32, P < 0.05). MF-TPD had higher specificity (77% vs. 55%, P < 0.05) and accuracy (89% vs. 80%, P < 0.05) than did S-TPD. Conclusion: MF processing of MPS improves CAD detection in obese patients.

KW - Coronary artery disease

KW - Gated SPECT

KW - Image registration

KW - Image warping

KW - Motion correction

KW - Myocardial perfusion

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JO - Journal of Nuclear Medicine

JF - Journal of Nuclear Medicine

IS - 7

ER -

Motion-frozen myocardial perfusion SPECT improves detection of coronary artery disease in obese patients

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