TY - JOUR
T1 - Motion-frozen myocardial perfusion SPECT improves detection of coronary artery disease in obese patients
AU - Suzuki, Yasuyuki
AU - Slomka, Piotr J.
AU - Wolak, Arik
AU - Ohba, Muneo
AU - Suzuki, Shoji
AU - Ling, De Yang
AU - Germano, Guido
AU - Berman, Daniel S.
PY - 2008/7/1
Y1 - 2008/7/1
N2 - In this study, we compared the diagnostic performance of the standard SPECT with motion-frozen (MF) myocardial perfusion SPECT (MPS) in obese patients. Methods: A total of 90 consecutive obese patients (body mass index, 30.1-46.8, average, 34.3 6 3.6; age, 63 6 12 y; 30% women) underwent standard supine rest 201Tl/stress 99mTc dual-isotope gated MPS and cardiac catheterization within 3mo. MF images were obtained by nonlinear warping of cardiac phases to the end-diastolic position. Total perfusion deficit (TPD) was obtained for summed (S-TPD) and motion-frozen (MF-TPD) datasets with sex-specific standard and MF normal limits. Results: The area under the receiver-operating-characteristic (ROC) curve for detection of coronary artery disease (CAD) by MF-TPD was significantly larger than that for S-TPD (0.93 ± 0.25 vs. 0.88 ± 0.32, P < 0.05). MF-TPD had higher specificity (77% vs. 55%, P < 0.05) and accuracy (89% vs. 80%, P < 0.05) than did S-TPD. Conclusion: MF processing of MPS improves CAD detection in obese patients.
AB - In this study, we compared the diagnostic performance of the standard SPECT with motion-frozen (MF) myocardial perfusion SPECT (MPS) in obese patients. Methods: A total of 90 consecutive obese patients (body mass index, 30.1-46.8, average, 34.3 6 3.6; age, 63 6 12 y; 30% women) underwent standard supine rest 201Tl/stress 99mTc dual-isotope gated MPS and cardiac catheterization within 3mo. MF images were obtained by nonlinear warping of cardiac phases to the end-diastolic position. Total perfusion deficit (TPD) was obtained for summed (S-TPD) and motion-frozen (MF-TPD) datasets with sex-specific standard and MF normal limits. Results: The area under the receiver-operating-characteristic (ROC) curve for detection of coronary artery disease (CAD) by MF-TPD was significantly larger than that for S-TPD (0.93 ± 0.25 vs. 0.88 ± 0.32, P < 0.05). MF-TPD had higher specificity (77% vs. 55%, P < 0.05) and accuracy (89% vs. 80%, P < 0.05) than did S-TPD. Conclusion: MF processing of MPS improves CAD detection in obese patients.
KW - Coronary artery disease
KW - Gated SPECT
KW - Image registration
KW - Image warping
KW - Motion correction
KW - Myocardial perfusion
UR - http://www.scopus.com/inward/record.url?scp=46749084307&partnerID=8YFLogxK
U2 - 10.2967/jnumed.108.050997
DO - 10.2967/jnumed.108.050997
M3 - Article
C2 - 18552133
AN - SCOPUS:46749084307
SN - 1535-5667
VL - 49
SP - 1075
EP - 1079
JO - Journal of nuclear medicine : official publication, Society of Nuclear Medicine
JF - Journal of nuclear medicine : official publication, Society of Nuclear Medicine
IS - 7
ER -