Molecular characterization and immune responsive expression of feline MDA5 gene

Ryota Koba, Sakurako Shoji, Sawami Yoshimura, Yukinobu Tohya

Research output: Contribution to journalComment/debate


The retinoic acid-inducible gene-I-like receptor (RLR) family is a group of cytosolic RNA helicase proteins that play an important role in sensing viral RNAs. Melanoma differentiation-associated gene 5 (MDA5), an RLR protein, recognizes viral double-stranded RNA and 5’-triphosphate single-stranded RNA in the cytoplasm for the expression of type I interferon (IFN). The expression of MDA5 is also induced by type I IFN. In the present study, we determined the complete coding sequence of the feline MDA5 gene, and analyzed its structure. In addition, we examined tissue expression patterns, inducibilities of the feline MDA5 by polyinosinic-polycytidylic acid and type I IFN, and a functional role of feline MDA5 on type I IFN expression.

Original languageEnglish
Pages (from-to)1266-1270
Number of pages5
JournalJournal of Veterinary Medical Science
Issue number8
Publication statusPublished - Aug 2018


  • Cat
  • Innate immunity
  • Interferon
  • Melanoma differentiation-associated gene 5 (MDA5)


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