Metabolomics Research in Periodontal Disease by Mass Spectrometry

Sachio Tsuchida, Tomohiro Nakayama

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)


Periodontology is a newer field relative to other areas of dentistry. Remarkable progress has been made in recent years in periodontology in terms of both research and clinical applications, with researchers worldwide now focusing on periodontology. With recent advances in mass spectrometry technology, metabolomics research is now widely conducted in various research fields. Metabolomics, which is also termed metabolomic analysis, is a technology that enables the comprehensive analysis of small-molecule metabolites in living organisms. With the development of metabolite analysis, methods using gas chromatography–mass spectrometry, liquid chromatography–mass spectrometry, capillary electrophoresis–mass spectrometry, etc. have progressed, making it possible to analyze a wider range of metabolites and to detect metabolites at lower concentrations. Metabolomics is widely used for research in the food, plant, microbial, and medical fields. This paper provides an introduction to metabolomic analysis and a review of the increasing applications of metabolomic analysis in periodontal disease research using mass spectrometry technology.

Original languageEnglish
Article number2864
Issue number9
Publication statusPublished - 1 May 2022


  • GC-MS
  • LC-MS/MS
  • metabolomics research
  • periodontal disease
  • periodontitis
  • proteomic analysis


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