Malignant transformation of T-cell large granular lymphocyte leukemia in a dog

Tomoko Takahashi, Isao Otani, Masaru Okuda, Masashi Inoue, Kanako Ito, Manabu Sakai, Hiroshi Koie, Yoshiki Yamaya, Toshihiro Watari, Tsuneo Sato, Kiichi Kanayama, Mikihiko Tokuriki

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7 Citations (Scopus)


An 8-year-old spayed female Golden Retriever was referred to us for evaluation of mild lymphocytosis. The peripheral lymphocytes were comprised of mostly large granular lymphocytes (LGLs), and flow cytometry showed that they were mostly CD3+8+ T lymphocytes. Clonal rearrangement of the T-cell receptor gene was identified in the peripheral blood, and the dog was therefore diagnosed with LGL chronic leukemia. The dog was subclinical without treatment until hospitalization on day 154, at which point the lymphocytes looked like lymphoblasts and the surface markers changed to CD3-8-. This was regarded as malignant transformation from LGL chronic leukemia to the acute type. Sequential chemotherapy was started, but the dog died on day 190. Necropsy revealed tumor cell infiltration into the heart, skin, and brain.

Original languageEnglish
Pages (from-to)677-681
Number of pages5
JournalJournal of Veterinary Medical Science
Issue number6
Publication statusPublished - Jun 2007


  • Flow cytometry
  • Large granular lymphocyte leukemia
  • Malignant transformation


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