Male-dominant hepatitis a outbreak observed among non-hiv-infected persons in the northern part of tokyo, japan

Masayuki Honda; Hiroyuki Asakura; Tatsuo Kanda; Yoshiko Somura; Tomotaka Ishii; Yoichiro Yamana; Tomohiro Kaneko; Taku Mizutani; Hiroshi Takahashi; Mariko Kumagawa; Reina Sasaki; Ryota Masuzaki; Shini Kanezawa; Kazushige Nirei; Hiroaki Yamagami; Naoki Matsumoto; Mami Nagashima; Takashi Chiba; Mitsuhiko Moriyama

doi:10.3390/v13020207

Male-dominant hepatitis a outbreak observed among non-hiv-infected persons in the northern part of tokyo, japan

Masayuki Honda, Hiroyuki Asakura, Tatsuo Kanda, Yoshiko Somura, Tomotaka Ishii, Yoichiro Yamana, Tomohiro Kaneko, Taku Mizutani, Hiroshi Takahashi, Mariko Kumagawa, Reina Sasaki, Ryota Masuzaki, Shini Kanezawa, Kazushige Nirei, Hiroaki Yamagami, Naoki Matsumoto, Mami Nagashima, Takashi Chiba, Mitsuhiko Moriyama

School of Medicine

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Recently, we experienced an outbreak of acute hepatitis A virus (HAV) infection between 2018 and 2020. Herein, we describe this male-dominant HAV infection outbreak observed among non-human immunodeficiency virus (HIV)-infected persons in the northern part of Tokyo, Japan. Clinical information was collected from patient interviews and from medical record descriptions. In the present study, 21 patients were retrospectively analyzed. A total of 90.4 and 33.3% of patients were males, and men who have sex with men (MSM), respectively. The total bilirubin levels and platelet counts tended to be lower in the MSM group than in the non-MSM group. C-reactive protein (CRP) levels tended to be higher in acute liver failure (ALF) patients than in non-ALF patients. Prolonged cholestasis was observed in one patient (4.8%). We also found that 18 HAV isolates belonged to HAV subgenotype IA/subgroup 13 (S13), which clustered with the HAV isolate (KX151459) that was derived from an outbreak of HAV infection among MSM in Taiwan in 2015. Our results suggest that the application of antivirals against HAV, as well as HAV vaccines, would be useful for the treatment and prevention of severe HAV infection.

Original language	English
Article number	207
Journal	Viruses
Volume	13
Issue number	2
DOIs	https://doi.org/10.3390/v13020207
Publication status	Published - Feb 2021

Keywords

HAV
Male-dominant
Men who have sex with men
Non-HIV
Sexually transmitted diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Honda, M., Asakura, H., Kanda, T., Somura, Y., Ishii, T., Yamana, Y., Kaneko, T., Mizutani, T., Takahashi, H., Kumagawa, M., Sasaki, R., Masuzaki, R., Kanezawa, S., Nirei, K., Yamagami, H., Matsumoto, N., Nagashima, M., Chiba, T., & Moriyama, M. (2021). Male-dominant hepatitis a outbreak observed among non-hiv-infected persons in the northern part of tokyo, japan. Viruses, 13(2), Article 207. https://doi.org/10.3390/v13020207

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title = "Male-dominant hepatitis a outbreak observed among non-hiv-infected persons in the northern part of tokyo, japan",

abstract = "Recently, we experienced an outbreak of acute hepatitis A virus (HAV) infection between 2018 and 2020. Herein, we describe this male-dominant HAV infection outbreak observed among non-human immunodeficiency virus (HIV)-infected persons in the northern part of Tokyo, Japan. Clinical information was collected from patient interviews and from medical record descriptions. In the present study, 21 patients were retrospectively analyzed. A total of 90.4 and 33.3% of patients were males, and men who have sex with men (MSM), respectively. The total bilirubin levels and platelet counts tended to be lower in the MSM group than in the non-MSM group. C-reactive protein (CRP) levels tended to be higher in acute liver failure (ALF) patients than in non-ALF patients. Prolonged cholestasis was observed in one patient (4.8%). We also found that 18 HAV isolates belonged to HAV subgenotype IA/subgroup 13 (S13), which clustered with the HAV isolate (KX151459) that was derived from an outbreak of HAV infection among MSM in Taiwan in 2015. Our results suggest that the application of antivirals against HAV, as well as HAV vaccines, would be useful for the treatment and prevention of severe HAV infection.",

keywords = "HAV, Male-dominant, Men who have sex with men, Non-HIV, Sexually transmitted diseases",

author = "Masayuki Honda and Hiroyuki Asakura and Tatsuo Kanda and Yoshiko Somura and Tomotaka Ishii and Yoichiro Yamana and Tomohiro Kaneko and Taku Mizutani and Hiroshi Takahashi and Mariko Kumagawa and Reina Sasaki and Ryota Masuzaki and Shini Kanezawa and Kazushige Nirei and Hiroaki Yamagami and Naoki Matsumoto and Mami Nagashima and Takashi Chiba and Mitsuhiko Moriyama",

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doi = "10.3390/v13020207",

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Honda, M, Asakura, H, Kanda, T, Somura, Y, Ishii, T, Yamana, Y, Kaneko, T, Mizutani, T, Takahashi, H, Kumagawa, M, Sasaki, R, Masuzaki, R, Kanezawa, S, Nirei, K, Yamagami, H, Matsumoto, N, Nagashima, M, Chiba, T & Moriyama, M 2021, 'Male-dominant hepatitis a outbreak observed among non-hiv-infected persons in the northern part of tokyo, japan', Viruses, vol. 13, no. 2, 207. https://doi.org/10.3390/v13020207

TY - JOUR

T1 - Male-dominant hepatitis a outbreak observed among non-hiv-infected persons in the northern part of tokyo, japan

AU - Honda, Masayuki

AU - Asakura, Hiroyuki

AU - Kanda, Tatsuo

AU - Somura, Yoshiko

AU - Ishii, Tomotaka

AU - Yamana, Yoichiro

AU - Kaneko, Tomohiro

AU - Mizutani, Taku

AU - Takahashi, Hiroshi

AU - Kumagawa, Mariko

AU - Sasaki, Reina

AU - Masuzaki, Ryota

AU - Kanezawa, Shini

AU - Nirei, Kazushige

AU - Yamagami, Hiroaki

AU - Matsumoto, Naoki

AU - Nagashima, Mami

AU - Chiba, Takashi

AU - Moriyama, Mitsuhiko

PY - 2021/2

Y1 - 2021/2

N2 - Recently, we experienced an outbreak of acute hepatitis A virus (HAV) infection between 2018 and 2020. Herein, we describe this male-dominant HAV infection outbreak observed among non-human immunodeficiency virus (HIV)-infected persons in the northern part of Tokyo, Japan. Clinical information was collected from patient interviews and from medical record descriptions. In the present study, 21 patients were retrospectively analyzed. A total of 90.4 and 33.3% of patients were males, and men who have sex with men (MSM), respectively. The total bilirubin levels and platelet counts tended to be lower in the MSM group than in the non-MSM group. C-reactive protein (CRP) levels tended to be higher in acute liver failure (ALF) patients than in non-ALF patients. Prolonged cholestasis was observed in one patient (4.8%). We also found that 18 HAV isolates belonged to HAV subgenotype IA/subgroup 13 (S13), which clustered with the HAV isolate (KX151459) that was derived from an outbreak of HAV infection among MSM in Taiwan in 2015. Our results suggest that the application of antivirals against HAV, as well as HAV vaccines, would be useful for the treatment and prevention of severe HAV infection.

AB - Recently, we experienced an outbreak of acute hepatitis A virus (HAV) infection between 2018 and 2020. Herein, we describe this male-dominant HAV infection outbreak observed among non-human immunodeficiency virus (HIV)-infected persons in the northern part of Tokyo, Japan. Clinical information was collected from patient interviews and from medical record descriptions. In the present study, 21 patients were retrospectively analyzed. A total of 90.4 and 33.3% of patients were males, and men who have sex with men (MSM), respectively. The total bilirubin levels and platelet counts tended to be lower in the MSM group than in the non-MSM group. C-reactive protein (CRP) levels tended to be higher in acute liver failure (ALF) patients than in non-ALF patients. Prolonged cholestasis was observed in one patient (4.8%). We also found that 18 HAV isolates belonged to HAV subgenotype IA/subgroup 13 (S13), which clustered with the HAV isolate (KX151459) that was derived from an outbreak of HAV infection among MSM in Taiwan in 2015. Our results suggest that the application of antivirals against HAV, as well as HAV vaccines, would be useful for the treatment and prevention of severe HAV infection.

KW - HAV

KW - Male-dominant

KW - Men who have sex with men

KW - Non-HIV

KW - Sexually transmitted diseases

UR - http://www.scopus.com/inward/record.url?scp=85101480500&partnerID=8YFLogxK

U2 - 10.3390/v13020207

DO - 10.3390/v13020207

M3 - Article

C2 - 33573054

AN - SCOPUS:85101480500

SN - 1999-4915

VL - 13

JO - Viruses

JF - Viruses

IS - 2

M1 - 207

ER -

Male-dominant hepatitis a outbreak observed among non-hiv-infected persons in the northern part of tokyo, japan

Abstract

Keywords

UN SDGs

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