Ligature-induced periodontitis increased insulin resistance and triglyceride levels in wistar rats

Hideki Tanaka, Kumiko Nakai, Fumiko Murakami, Toyoko Morita, Yoji Yamazaki, Rieko Matsuike, Chika Shibata, Maki Nagasaki, Mai Kanda, Natsuko Tanabe, Takayuki Kawato, Masao Maeno

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5 Citations (Scopus)


In the present study, experimental periodontitis was induced by ligature in Wistar rats that were not on high-fat or high-carbohydrate diet. The metabolic and inflammatory parameters in the serum were examined in order to assess the effect of periodontitis-induced inflammation on metabolic syndrome in individual without the genetic and dietary risk factors. Ligature-induced experimental periodontitis increased monocyte chemoattractant protein-1 and triglyceride levels in the serum, as well as homeostasis model assessment of insulin resistance, based on the concentration of serum glucose and insulin in Wistar rats. Furthermore, elevated triglyceride levels and altered expression of genes associated with glucose and lipid metabolism were also observed in the liver of rats with experimental periodontitis, suggesting that the onset of periodontitis induced metabolic syndrome independent of genetic and dietary risk factors.

Original languageEnglish
Pages (from-to)261-267
Number of pages7
JournalJournal of Hard Tissue Biology
Issue number3
Publication statusPublished - 2017


  • Insulin resistance
  • Metabolic syndrome
  • Monocyte chemoattractant protein-1
  • Periodontitis
  • Triglyceride


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