Kinetics of lymphocyte subpopulations in allogeneic grafted scales of ginbuna crucian carp

Yasuhiro Shibasaki, Yuta Matsuura, Hideaki Toda, Nozomi Imabayashi, Tatsuyuki Nishino, Kosuke Uzumaki, Chihiro Hatanaka, Takeshi Yabu, Tadaaki Moritomo, Teruyuki Nakanishi

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

In mammals the rejection of allografts is primarily accomplished by cell-mediated immunity including T cells. Recently, considerable studies reveal the existence of helper and cytotoxic T cell subsets in fish. Here we investigate the kinetics of CD4+ and CD8α+ T cells along with sIgM+ cells and phagocytic cells in an allogeneic scale graft model using ginbuna crucian carp for understanding the mechanisms of cell-mediated immune response. The results showed that CD4+ T cells first infiltrated into allogeneic scales followed by CD8α+ and sIgM+ cells, and finally phagocytic cells appeared in the graft. Furthermore, most of the CD8α+ T cells appeared on the border of the allografted scales at the time of rejection. These results suggest that T cells play crucial roles and work together with other cell types for completion of allograft rejection.

Original languageEnglish
Pages (from-to)75-80
Number of pages6
JournalDevelopmental and Comparative Immunology
Volume52
Issue number1
DOIs
Publication statusPublished - 1 Sept 2015

Keywords

  • Allograft rejection
  • CD4
  • CD8
  • Ginbuna crucian carp
  • Phagocytic cells
  • Surface IgM positive cell

Fingerprint

Dive into the research topics of 'Kinetics of lymphocyte subpopulations in allogeneic grafted scales of ginbuna crucian carp'. Together they form a unique fingerprint.

Cite this