Abstract
In mammals the rejection of allografts is primarily accomplished by cell-mediated immunity including T cells. Recently, considerable studies reveal the existence of helper and cytotoxic T cell subsets in fish. Here we investigate the kinetics of CD4+ and CD8α+ T cells along with sIgM+ cells and phagocytic cells in an allogeneic scale graft model using ginbuna crucian carp for understanding the mechanisms of cell-mediated immune response. The results showed that CD4+ T cells first infiltrated into allogeneic scales followed by CD8α+ and sIgM+ cells, and finally phagocytic cells appeared in the graft. Furthermore, most of the CD8α+ T cells appeared on the border of the allografted scales at the time of rejection. These results suggest that T cells play crucial roles and work together with other cell types for completion of allograft rejection.
Original language | English |
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Pages (from-to) | 75-80 |
Number of pages | 6 |
Journal | Developmental and Comparative Immunology |
Volume | 52 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1 Sept 2015 |
Keywords
- Allograft rejection
- CD4
- CD8
- Ginbuna crucian carp
- Phagocytic cells
- Surface IgM positive cell