Isolated lymphoid follicles are not IgA inductive sites for recombinant Salmonella

Tomomi Hashizume, Fumiki Momoi, Tomoko Kurita-Ochiai, Shuichi Kaminogawa, Akira Hosono, Kosuke Kataoka, Noriko Shinozaki-Kuwahara, Mi Na Kweon, Masafumi Yamamoto

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


In this study, we investigated whether isolated lymphoid follicles (ILF) play a role in the regulation of intestinal IgA antibody (Ab) responses. The transfer of wild type (WT) bone marrow (BM) to lymphotoxin-α-deficient (LTα-/-) mice resulted in the formation of mature ILF containing T cells, B cells, and FDC clusters in the absence of mesenteric lymph nodes and Peyer's patches. Although the ILF restored total IgA Abs in the intestine, antigen (Ag)-specific IgA responses were not induced after oral immunization with recombinant Salmonella expressing fragment C of tetanus toxin. Moreover, Ag-specific cell proliferation was not detected in the ILF. Interestingly, no IgA anti-LPS Abs were detected in the fecal extracts of LTα-/- mice reconstituted with WT BM. On the basis of these findings, ILF can be presumed to play a role in the production of IgA Abs, but lymphoid nodules are not inductive sites for the regulation of Ag-specific intestinal IgA responses to recombinant Salmonella.

Original languageEnglish
Pages (from-to)388-393
Number of pages6
JournalBiochemical and Biophysical Research Communications
Issue number2
Publication statusPublished - 24 Aug 2007


  • IgA
  • Isolated lymphoid follicles
  • Recombinant Salmonella


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