Isochromophilol A, a new azaphilone isolated from Penicillium sp. RO369, a leaf litter inhabiting fungus from Tsuga diversifolia

Kan'ichiro Ishiuchi; Dai Hirose; Yoriko Takahashi; Ryu Miyagawa; Kohei Watanabe; Susumu Kitanaka

doi:10.3987/COM-19-14164

Isochromophilol A, a new azaphilone isolated from Penicillium sp. RO369, a leaf litter inhabiting fungus from Tsuga diversifolia

Kan'ichiro Ishiuchi, Dai Hirose, Yoriko Takahashi, Ryu Miyagawa, Kohei Watanabe, Susumu Kitanaka

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

A new sclerotiorin-type azaphilone, isochromophilol A (1), was isolated from Penicillium sp. RO369 associated with Tsuga diversifolia, along with eight known compounds (2−9). The structure of 1 was elucidated on the basis of spectroscopic data. Isochromophilol A (1) (16 μg) showed weak anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity with an inhibition diameter of 8.8 ± 1.0 mm.

Original language	English
Pages (from-to)	1574-1579
Number of pages	6
Journal	Heterocycles
Volume	98
Issue number	11
DOIs	https://doi.org/10.3987/COM-19-14164
Publication status	Published - 2019

Access to Document

10.3987/COM-19-14164

Cite this

@article{8dff6ad295b0450784271470b2de710a,

title = "Isochromophilol A, a new azaphilone isolated from Penicillium sp. RO369, a leaf litter inhabiting fungus from Tsuga diversifolia",

abstract = "A new sclerotiorin-type azaphilone, isochromophilol A (1), was isolated from Penicillium sp. RO369 associated with Tsuga diversifolia, along with eight known compounds (2−9). The structure of 1 was elucidated on the basis of spectroscopic data. Isochromophilol A (1) (16 μg) showed weak anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity with an inhibition diameter of 8.8 ± 1.0 mm.",

author = "Kan'ichiro Ishiuchi and Dai Hirose and Yoriko Takahashi and Ryu Miyagawa and Kohei Watanabe and Susumu Kitanaka",

note = "Publisher Copyright: {\textcopyright} 2019 The Japan Institute of Heterocyclic Chemistry.",

year = "2019",

doi = "10.3987/COM-19-14164",

language = "English",

volume = "98",

pages = "1574--1579",

journal = "Heterocycles",

issn = "0385-5414",

publisher = "Japan Institute of Heterocyclic Chemistry",

number = "11",

}

TY - JOUR

T1 - Isochromophilol A, a new azaphilone isolated from Penicillium sp. RO369, a leaf litter inhabiting fungus from Tsuga diversifolia

AU - Ishiuchi, Kan'ichiro

AU - Hirose, Dai

AU - Takahashi, Yoriko

AU - Miyagawa, Ryu

AU - Watanabe, Kohei

AU - Kitanaka, Susumu

PY - 2019

Y1 - 2019

N2 - A new sclerotiorin-type azaphilone, isochromophilol A (1), was isolated from Penicillium sp. RO369 associated with Tsuga diversifolia, along with eight known compounds (2−9). The structure of 1 was elucidated on the basis of spectroscopic data. Isochromophilol A (1) (16 μg) showed weak anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity with an inhibition diameter of 8.8 ± 1.0 mm.

AB - A new sclerotiorin-type azaphilone, isochromophilol A (1), was isolated from Penicillium sp. RO369 associated with Tsuga diversifolia, along with eight known compounds (2−9). The structure of 1 was elucidated on the basis of spectroscopic data. Isochromophilol A (1) (16 μg) showed weak anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity with an inhibition diameter of 8.8 ± 1.0 mm.

UR - http://www.scopus.com/inward/record.url?scp=85078212499&partnerID=8YFLogxK

U2 - 10.3987/COM-19-14164

DO - 10.3987/COM-19-14164

M3 - Article

AN - SCOPUS:85078212499

SN - 0385-5414

VL - 98

SP - 1574

EP - 1579

JO - Heterocycles

JF - Heterocycles

IS - 11

ER -

Isochromophilol A, a new azaphilone isolated from Penicillium sp. RO369, a leaf litter inhabiting fungus from Tsuga diversifolia

Abstract

Access to Document

Other files and links

Fingerprint

Cite this