TY - JOUR
T1 - Intestinal Failure-Associated Liver Disease and Eicosapentaenoic Acid/Arachidonic Acid Ratio
AU - Miura, Wataru
AU - Nagano, Nobuhiko
AU - Kato, Ryota
AU - Okahashi, Aya
AU - Yoshikawa, Kayo
AU - Ohashi, Kensuke
AU - Koshinaga, Tsugumichi
AU - Morioka, Ichiro
N1 - Publisher Copyright:
© 2019, Dr. K C Chaudhuri Foundation.
PY - 2019/6/1
Y1 - 2019/6/1
N2 - Intestinal failure-associated liver disease (IFALD) is a fatal complication of short bowel syndrome managed with parenteral nutrition. A clinical cohort study reported the usefulness of parenteral administration of fish-derived omega-3 fatty acids in improving IFALD; however, no biomarker has been developed as yet. The authors report the case of a preterm infant with IFALD complicated by extensive short bowel syndrome. Intravenous administration of omega-3 fatty acids were introduced using Omegaven®at the age of 4 mo for IFALD. The IFALD improved with an increase in Eicosapentaenoic acid (EPA)/ Arachidonic acid (AA) ratio (from 0.08 to 1.99) 7 d after the intravenous treatment. It is important to administer omega-3 fatty acids intravenously at an early stage for IFALD associated with extensive short bowel syndrome. A low EPA/AA ratio may be a serum marker of disease activity in IFALD.
AB - Intestinal failure-associated liver disease (IFALD) is a fatal complication of short bowel syndrome managed with parenteral nutrition. A clinical cohort study reported the usefulness of parenteral administration of fish-derived omega-3 fatty acids in improving IFALD; however, no biomarker has been developed as yet. The authors report the case of a preterm infant with IFALD complicated by extensive short bowel syndrome. Intravenous administration of omega-3 fatty acids were introduced using Omegaven®at the age of 4 mo for IFALD. The IFALD improved with an increase in Eicosapentaenoic acid (EPA)/ Arachidonic acid (AA) ratio (from 0.08 to 1.99) 7 d after the intravenous treatment. It is important to administer omega-3 fatty acids intravenously at an early stage for IFALD associated with extensive short bowel syndrome. A low EPA/AA ratio may be a serum marker of disease activity in IFALD.
KW - Eicosapentaenoic acid/Arachidonic acid ratio
KW - Intestinal failure-associated liver disease
KW - Intravenous administration
KW - Omega-3 fatty acids
KW - Severe short bowel syndrome
UR - http://www.scopus.com/inward/record.url?scp=85061621570&partnerID=8YFLogxK
U2 - 10.1007/s12098-019-02895-7
DO - 10.1007/s12098-019-02895-7
M3 - Article
C2 - 30761448
AN - SCOPUS:85061621570
SN - 0019-5456
VL - 86
SP - 548
EP - 550
JO - Indian Journal of Pediatrics
JF - Indian Journal of Pediatrics
IS - 6
ER -