Interval Breast Cancer with Neuroendocrine Differentiation

Kenichi Sakurai, Shigeru Fujisaki, Keita Adachi, Shuhei Suzuki, Yuki Masuo, Saki Nagashima, Yukiko Hara, Ryouichi Tomita, Kenji Gonda, Tomohiro Hirano, Katsuhisa Enomoto, Sadao Amano

Research output: Contribution to journalArticlepeer-review


We report a case of interval breast cancer that was an invasive ductal carcinoma of the breast with neuroendocrine differentiation. The patient was a 66-year-old woman who had a breast lump. She had received breast cancer screening every other year. The last screening was 1 year and 6 months prior to diagnosis. A core needle biopsy for breast tumor led to a diagnosis of invasive ductal carcinoma. Breast conserving surgery plus sentinel lymph node biopsy was performed. The pathological diagnosis from the resected surgical specimen was invasive ductal carcinoma with neuroendocrine differentiation, positive for ER and PgR, and negative for HER2/neu protein expression. The surgical margins were negative, and there was no metastasis in the sentinel lymph node. She was administered radiation therapy and adjuvant endocrine therapy. Two years after surgery, she is well without metastasis.

Original languageEnglish
Pages (from-to)1770-1772
Number of pages3
JournalJapanese Journal of Cancer and Chemotherapy
Issue number12
Publication statusPublished - 1 Nov 2015


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